• 1
    Di Bisceglie AM. Hepatitis C Lancet 1998; 351:351355.
  • 2
    Vento S, Cainelli F. Does hepatitis C virus cause severe liver disease only in people who drink alcohol? Lancet Inf Dis 2002; 2:303309.
  • 3
    Peters MG, Terrault NA. Alcohol use and hepatitis C. Hepatology 2002; 36:S220S225.
  • 4
    Ostapowicz G, Watzon KJR, Locarnini SA, Desmond PV. Role of alcohol in the progression of liver disease caused by hepatitis C virus infection. Hepatology 1998; 27:17301735.
  • 5
    Corrao G, Aricò S. Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis. Hepatology 1998; 27:914919.
  • 6
    Westin J, Lagging LM, Spak F, Aires N, Svensson E, Lindh M, Dhillon AP, et al. Moderate alcohol intake increases fibrosis progression in untreated patients with hepatitis C virus infection. J Virol Hepatol 2002; 9:235241.
  • 7
    Hassan MM, Hwang LY, Hatten CJ, Swaim M, Li D, Abbruzzese JL, Beasley P, et al. Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes. Hepatology 2002; 36:12061213.
  • 8
    Degos F. Hepatitis C and alcohol. J Hepatol 1999; 31(Suppl 1):113119.
  • 9
    Farinati F, Cardin R, De Maria N, Della Libera G, Marafin C, Lecis E, Burra P, et al. Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis. J Hepatol 1995; 22:449456.
  • 10
    De Maria N, Colantoni A, Fagiuoli S, Liu GJ, Rogers BK, Farinati F, VanThiel DH, et al. Association between reactive oxygen species and disease activity in chronic hepatitis C. Free Radic Biol Med 1996; 21:291295.
  • 11
    Romero MJ, Bosch-Morell F, Romero B, Rodrigo JM, Serra MA, Romero FJ. Serum malondialdehyde: possible use for the clinical managements of chronic hepatitis C patients. Free Radic Biol Med 1998; 25:993997.
  • 12
    Barbaro G, Di Lorenzo G, Ribersani M, Soldini M, Giancaspro G, Bellomo G, Belloni G, et al. Serum and hepatic glutathione concentrations in chronic hepatitis C patients related to hepatitis C virus genotype. J Hepatol 1999; 30:774782.
  • 13
    Kageyama F, Kobayashi Y, Kawasaki T, Toyokuni S, Uchida K, Nakamura H. Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C. Am J Gastrenterol 2000; 95:10411050.
    Direct Link:
  • 14
    Jain SK, Pemberton PW, Smith A, McMahon RTF, Burrows PC, Aboutwerat A, Warnes TW. Oxidative stress in chronic hepatitis C: not just a feature of late stage disease. J Hepatol 2002; 36:805811.
  • 15
    Moriya K, Nakagawa K, Santa T, Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, et al. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res 2001; 61:43654370.
  • 16
    Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lenon SM, Weiman SA. Mitochondrial injury, oxidative stress and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002; 122:366375.
  • 17
    Albano E. Free radicals and alcohol-induced liver injury. In: ShermanCDIN, PreedyVR, WatsonRR, eds. Ethanol and the Liver. London: Taylor and Francis, 2002:153190.
  • 18
    Clot P, Tabone M, Aricò S, Albano E. Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake. Gut 1994; 35:16371643.
  • 19
    Aleynik SI, Leo MA, Aleynik MK, Lieber CS. Increased circulating products of lipid peroxidation in patients with alcoholic liver disease. Alcohol Clin Exp Res 1998; 22:192196.
  • 20
    Meager EA, Barry OP, Burke A, Lucey MR, Lawson JA, Rokach J, FitzGerald GA. Alcohol-induced generation of lipid peroxidation products in humans. J Clin Invest 1999; 104:805813.
  • 21
    Niemelä O, Parkkila S, Britton RS, Brunt E, Janney C, Bacon B. Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver disease. J Lab Clin Med 1999: 133:451460.
  • 22
    Palinski W, Ylä-Herttuala S, Rosenfeld ME, Butler S, Socher SA, Parthasarathy S, Curtiss LK, et al. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low-density lipoprotein. Atherosclerosis 1990; 10:325335.
  • 23
    Rolla R, Vay D, Mottaran E, Parodi M, Traverso N, Aricò S, Sartori M, et al. Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcoholic liver disease. Hepatology 2000; 31:878884.
  • 24
    Viitala K, Makkonen K, Israel Y, Lehtimäki T, Jaakkola O, Koivula T, Blake JE, et al. Autoimmune response against oxidant stress and acetaldehyde-derived epitopes in human alcohol consumers. Alcohol Clin Exp Res 2000; 24:11031109.
  • 25
    Mottaran E, Stewart SF, Rolla R, Vay D, Cipriani V, Moretti MG, Vidali M, et al. Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease. Free Radic Biol Med 2002; 32:3848.
  • 26
    Rolla R, Vay D, Mottaran E, Parodi M, Vidali M, Sartori M, Bellomo G, et al. Anti-phospholipid antibodies associated with alcoholic liver disease specifically recognise oxidised phospholipids. Gut 2001; 49:852859.
  • 27
    Corrao G, Aricò S, Russo G. Alcohol consumption and non-cirrhotic chronic hepatitis: a case-control study. Int J Epidemiol 1991; 20:10371042.
  • 28
    Sartori M, Andorno S, La Terra G, Boldorini R, Leone F, Pittau S, Zecchina G, et al. Evaluation of iron status in patients with chronic hepatitis C. Ital J Gastroenterol Hepatol 1998; 30:396401.
  • 29
    Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Guadat F, Denk H, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22:696699.
  • 30
    Paradis V, Mathurin P, Kolliger M, Imbert-Bismut F, Charlotte F, Piton A, Opolon P, et al. In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features. J Clin Pathol 1997; 50:401406.
  • 31
    Barbaro G, Di Lorenzo G, Asti A, Ribersani M, Belloni G, Grisorio B, Filice G, et al. Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings. Am J Gastroenterol 1999; 94:21982205.
    Direct Link:
  • 32
    Thorburn D, Curry G, Spooner R, Spence E, Oien K, Halls D, Fox R, et al. The role of iron and heamochromatosis gene mutations in the progression of liver disease in chronic hepatitis. Gut 2002; 50:248252.
  • 33
    Hoek JB, Cahill A, Pastorino JG. Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 2002; 122:20492063.
  • 34
    Vendemiale G, Grattagliano I, Portincase P, Serviddio G, Palasciano G, Altomare E. Oxidative stress in symptom-free HCV carriers: relation with ALT flare-up. Eur J Clin Invest 2001; 31:5463.
  • 35
    Sefarty L, Poujol-Robert A, Carbonell N, Chazouillères O, Poupon RE, Poupon R. Effect of the interaction between steatosis and alcohol intake on liver fibrosis progression in chronic hepatits C. Am J Gastroenterol 2002; 97:18071812.
    Direct Link: