• 1
    Amodio P, Del Piccolo F, Marchetti P, Angeli P, Iemmolo R, Caregaro L, Merkel C, et al. Clinical features and survival of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests. Hepatology 1999; 29:16621667.
  • 2
    Marchesini G, Bianchi G, Amodio P, Salerno F, Merli M, Panella C, Loguercio C, et al. Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology 2001; 120:170178.
  • 3
    Conn HO, Leevy CM, Vlahcevic ZR, Rodgers JB, Maddrey WC, Seef L, Levy LL. Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy:a double blind controlled trial. Gastroenterology 1977; 72:573583.
  • 4
    Conn HO. Quantifying the severity of hepatic encephalopathy. In: ConnHO, BircherJ, eds. Hepatic Encephalopathy: Syndromes and therapies. East Lansing, MI: Medi-Ed Press, 1993;1326.
  • 5
    Kircheis G, Wettstein M, Timmermann L, Schnitzler A, Haussinger D. Critical flicker frequency for quantification of low-grade hepatic encephalopathy. Hepatology 2002; 35:357366.
  • 6
    Weissenborn K. Minimal hepatic encephalopathy: a permanent source of discussion. Hepatology 2002; 35:494496.
  • 7
    Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy—definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002; 35:716721.
  • 8
    Inoue E, Hori S, Narumi I, Fujita M, Kuriyama K, Kodota T, Kuroda T. Portal-systemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MR images. Radiology 1991; 179:551555.
  • 9
    Pomier-Layrargues G, Spahr L, Butterworth RF. Increased manganese concentrations in pallidum of cirrhotic patients. Lancet 1995; 345:735.
  • 10
    Krieger D, Krieger S, Jansen O, Gass P, Theilmann L, Lichtnecker H. Manganese and hepatic encephalopathy. Lancet 1995; 346:270274.
  • 11
    Spahr L, Vingerhoets F, Lazeyras F, Delavelle J, DuPasquier R, Giostra E, Mentha G, et al. Magnetic resonance imaging and proton spectroscopic alterations correlate with parkinsonian signs in patients with cirrhosis. Gastroenterology 2000; 119:774781.
  • 12
    Rovira A, Grive E, Pedraza S, Rovira A, Alonso J. Magnetization transfer ratio values and proton MR spectroscopy of normal-appearing cerebral white matter in patients with liver cirrhosis. Am J Neuroradiol 2001; 22:11371142.
  • 13
    Cordoba J, Alonso J, Rovira A, Jacas C, Sanpedro F, Castells L, Vargas V, et al. The development of low-grade cerebral edema in cirrhosis is supported by the evolution of (1)H-magnetic resonance abnormalities after liver transplantation. J Hepatol 2001; 35:598604.
  • 14
    Lucchini R, Albini E, Placidi D, Gasparotti R, Pigozzi MG, Montani G, Alessio L. Brain magnetic resonance imaging and manganese exposure. Neurotoxicology 2000; 21:769775.
  • 15
    Rovira A, Cordoba J, Sanpedro F, Grive E, Rovira-Gols A, Alonso J. Normalization of T2 signal abnormalities in hemispheric white matter with liver transplant. Neurology 2002; 59:335341.
  • 16
    Haussinger D, Laubenberger J, vom Dahl S, Ernst T, Bayer S, Lange M, Gerok W, Hennig J. Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology 1994; 107:14751480.
  • 17
    Haussinger D, Kircheis G, Fischer R, Schliess F, vom Dahl S. Hepatic encephalopathy in chronic liver disease: a clinical manifestation of astrocyte swelling and low-grade cerebral edema? J Hepatol 2000; 32:10351038.
  • 18
    Shah NJ, Steinhoff S, Zaitsev M. Pulsfolge, Kenspinresonanztomograph und Bildgebungsverfahren. 2000 German Patent Application Number: 10028171.0
  • 19
    Steinhoff S, Zaitsev M, Zilles K, Shah NJ. Fast T1 mapping with volume coverage. Magn Reson Med 2001; 46:131140.
  • 20
    Shah NJ, Zaitsev M, Steinhoff S, Zilles K. A new method for fast multislice T1 mapping. Neuroimage 2001; 14:11751185.
  • 21
    Zaitsev M, Steinhoff S, Shah NJ. Error Reduction and Parameter Optimisation of the TAPIR Method for Fast T1 Mapping. Magn Reson Med. 2003; 49:11211132.
  • 22
    Vienna Test System (WINWTS), Version 4.50, Dr. G. Schuhfried GmbH, Mödling, Austria, 1999.
  • 23
    Eberhardt G. Flimmerfrequenz-Analysator. Automatische Messmethode. Version 3.00. Dr. G. Schuhfried GmbH, Mödling, Austria, 1994.
  • 24
    Kubinger KD. Testtheoretische Probleme in der Computerdiagnostik. Z. f Arbeits Organisationspsychologie 1993; 3:130137.
  • 25
    Wöllersdorf E, Barolin GS. Flimmerverschmelzungs frequenzanalyse in der Differentialdiagnostik hirnorganischer Syndrome. Therapiewoche 1980; 30:80808088.
  • 26
    Smith JM, Misiak H. Critical flicker frequency (CFF) and psychotropic drugs in normal human subjects—a review. Psychopharmacology 1976; 47:175182.
  • 27
    Watanabe A. Cerebral changes in hepatic encephalopathy. J Gastroenterol Hepatol 1998; 13:752760.
  • 28
    Schomerus H, Hamster W, Blunck H, Reinhard U, Mayer K, Dölle W. Latent portosystemic encephalopathy. Nature of cerebral function defects and their effect on fitness to drive. Dig Dis Sci 1981; 16:321328.
  • 29
    Pomier-Layrargues G, Nguyen NH, Faucher C, Giguére JF, Butterworth RF. Subclinical hepatic encephalopathy in cirrhotic patients:prevalence and relationship to liver function. Can J Clin Gastroenterol 1991; 5:121125.
  • 30
    Quero JC, Schalm SW. Subclinical hepatic encephalopathy. Semin Liver Dis 1996; 16:321328.
  • 31
    Hazell AS, Desjardins P, Butterworth RF. Chronic exposure of rat primary astrocyte cultures to manganese results in increased binding sites for the peripheral-type benzodiazepine receptor ligand 3H-PK 11195. Neurosci Lett 1999; 271:58.
  • 32
    Chen CJ, Liao SL. Oxidative stress involves astrocytic alterations induced by manganese. Exp Neurol 2002; 175:21625.
  • 33
    Hazell AS, Norenberg MD. Manganese decreases glutamate uptake in cultured astrocytes. Neurochem Res 1997; 22:14431447.
  • 34
    Hazell AS, Norenberg MD. Ammonia and manganese increase arginine uptake in cultured astrocytes. Neurochem Res 1998; 23:869873.
  • 35
    Butterworth RF. Neurotransmitter dysfunction in hepatic encephalopathy: new approaches and new findings. Metab Brain Dis 2001; 16:5565.