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Intractable diarrhea after liver transplantation for Byler's disease: Successful treatment with bile adsorptive resin

  1. Hiroto Egawa MD1,*,
  2. Tohru Yorifuji2,
  3. Ryo Sumazaki3,
  4. Akihiko Kimura4,
  5. Makoto Hasegawa3,
  6. Koichi Tanaka1

Article first published online: 30 DEC 2003

DOI: 10.1053/jlts.2002.34384

Issue

Liver Transplantation

Liver Transplantation

Volume 8, Issue 8, pages 714–716, August 2002

Additional Information

How to Cite

Egawa, H., Yorifuji, T., Sumazaki, R., Kimura, A., Hasegawa, M. and Tanaka, K. (2002), Intractable diarrhea after liver transplantation for Byler's disease: Successful treatment with bile adsorptive resin. Liver Transpl, 8: 714–716. doi: 10.1053/jlts.2002.34384

Author Information

  1. 1

    Department of Transplant Surgery, Kyoto University, Kyoto, Japan

  2. 2

    Department of Pediatrics, Kyoto University, Kyoto, Japan

  3. 3

    Department of Pediatrics, Tsukuba University, Tsukuba, Japan

  4. 4

    Department of Pediatrics, Kurume University, Kurume, Japan

*Department of Transplant Surgery, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan 606-8507. Telephone: 075-751-4323; FAX: 075-751-4322

Publication History

  1. Issue published online: 30 DEC 2003
  2. Article first published online: 30 DEC 2003

Funded by

  • grant-in-aid for research on Human Genome, Tissue Engineering Food Biotechnology
  • Health Science Research Grant from the Ministry of Health, Labor and Welfare of Japan

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Abstract

Intractable diarrhea and prolonged growth retardation after liver transplantation for Byler's disease are serious complications limiting the ultimate outcome of liver transplantation for this disease. However, details of these complications have not been documented thoroughly. Six patients with Byler's disease developed intractable diarrhea after living donor liver transplantation. Because of high bile acid concentrations in stool, four patients were treated with bile acid adsorptive resin for bile acid diarrhea, and all showed improved bowel movements. Four of these patients who were followed up for 1 year registered a significant height gain. Also, the cause of postoperative diarrhea and growth retardation in patients with Byler's disease after liver transplantation is discussed.

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