• Please log in or register to access this feature.

Original Article

You have full text access to this OnlineOpen article

Liver transplantation for hepatocellular carcinoma: Comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria

  1. Francis Y. Yao MD1,*,
  2. Linda Ferrell2,
  3. Nathan M. Bass1,
  4. Peter Bacchetti3,
  5. Nancy L. Ascher4,
  6. John P. Roberts4

Article first published online: 30 DEC 2003

DOI: 10.1053/jlts.2002.34892

Issue

Liver Transplantation

Liver Transplantation

Volume 8, Issue 9, pages 765–774, September 2002

Additional Information

How to Cite

Yao, F. Y., Ferrell, L., Bass, N. M., Bacchetti, P., Ascher, N. L. and Roberts, J. P. (2002), Liver transplantation for hepatocellular carcinoma: Comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria. Liver Transpl, 8: 765–774. doi: 10.1053/jlts.2002.34892

Author Information

  1. 1

    Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA

  2. 2

    Department of Pathology, University of California, San Francisco, San Francisco, CA

  3. 3

    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA

  4. 4

    Department of Surgery, University of California, San Francisco, San Francisco, CA

*Division of Gastroenterology, Department of Medicine, University of California, San Francisco, Box 0538, 513 Parnassus Ave, Room S-357, San Francisco, CA 94143-0538. Telephone: 415-514-0332; FAX: 415-476-0659

Publication History

  1. Issue published online: 30 DEC 2003
  2. Article first published online: 30 DEC 2003

Funded by

  • National Institutes of Health to the University of California, San Francisco Liver Center. Grant Number: P30DK26743

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (112K)

References

  • 1
    Bismuth H, Chiche L, Adam R, Castaing D, Diamond T, Dennison A. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg 1993; 218:145–151.
  • 2
    Romani F, Belli LS, Rondinara SF, De Carlis L, Rimoldi P, Riolo F, et al. The role of transplantation in small hepatocellular carcinoma complicating cirrhosis of the liver. J Am Coll Surg 1994; 178:379–384.
  • 3
    Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334:693–699.
  • 4
    Figueras J, Jaurrieta E, Valis C, Benasco C, Rafecas A, Xiol X, et al. Survival after liver transplantation in cirrhotic patients with and without hepatocellular carcinoma: A comparative study. Hepatology 1997; 25:1485–1489.
    Direct Link:
  • 5
    Llovet JM, Bruix J, Fuster J, Castells A, Garcia-Valdecasas C, Grande L, et al. Liver transplantation for small hepatocellular carcinoma: The Tumor–Node–Metastasis classification does not have prognostic power. Hepatology 1998; 27:1572–1577.
    Direct Link:
  • 6
    Yao FY, Ferrell L, Bass NM, Watson JJ, Bachetti P, Venook A, et al. Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival. Hepatology 2001; 33:1394–1403.
    Direct Link:
  • 7
    Herrero IJ, Sangro B, Quiroga J, Pardo F, Herraiz M, Cienfuegos A, et al. Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma. Liver Transpl 2001; 7:631–636.
    Direct Link:
  • 8
    McPeake JR, O'Grady JG, Zaman S, Portmann B, Wight DG, Tan KC, et al. Liver transplantation for primary hepatocellular carcinoma: Tumor size and number determine outcome. J Hepatol 1993; 18:226–234.
  • 9
    United Network for Organ Sharing. Available via the Internet: (http://www.unos.org). Accessed 10 December, 2001.
  • 10
    International Union Against Cancer (UICC). TNM Classification of Malignant Tumours. 5th ed. In: LHSobin, ChWittekind (eds). New York, NY: Wiley-Liss, 1997:74–77.
  • 11
    Marsh JW, Dvorchik I, Bonham CA, Iwatsuki S. Is the pathologic TNM staging system for patients with hepatoma predictive of outcome? Cancer 2000; 88:538–543.
    Direct Link:
  • 12
    Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60:646–649.
    Direct Link:
  • 13
    Edmondson H, Steiner P. Primary carcinoma of the liver: A study of 100 cases among 48,900 necropsies. Cancer 1954; 1:462–503.
    Direct Link:
  • 14
    Kalfleisch JD, Prentice RL. The Statistical Analysis of Failure Time Data. New York, NY: Wiley and Sons, 1990:15.
  • 15
    Regalia E, Coppa J, Pulvirenti A, Romito R, Schiavo M, Burgoa L, et al. Liver transplantation for small hepatocellular carcinoma in cirrhosis: Analysis of our experience. Transplant Proc 2001; 33:1442–1444.
  • 16
    Marsh JW, Dvorchik I, Iwatsuki S. UNOS' policy in upgrading patients with HCC awaiting liver transplantation: Too little too late [abstract]. Transplantation 2000(suppl);69:S139.
  • 17
    Klintmalm GB. Liver transplantation for hepatocellular carcinoma. A registry report of the impact of tumor characteristics on outcome. Ann Surg 1998; 228:479–490.
  • 18
    Adham M, Oussoultzoglou E, Dwerf C, Bancel B, Bizollon T, Rode A, et al. Results of orthotopic liver transplantation for liver cirrhosis in the presence of incidental and/or undetected hepatocellular carcinoma and tumour characteristics. Transpl Int 1998; 11(suppl):S197–200.
  • 19
    Kirimlioglu H, Dvorchick I, Ruppert K, Finkelstein S, Marsh JW, Iwatsuki S, et al. Hepatocellular carcinoma in native livers from patients treated with orthotopic liver transplantation: Biologic and therapeutic implications. Hepatology 2001; 34:502–510.
    Direct Link:
  • 20
    Tamura S, Kato T, Berho M, Misiakos EP, O'Brien C, Reddy KR, et al. Impact of histologic grade of hepatocellular carcinoma on the outcome of liver transplantation. Arch Surg 2001; 136:25–30.
  • 21
    O'Grady JG, Polson RJ, Rolles K, Calne RY, Williams R. Liver transplantation for malignant disease: Results in 93 consecutive patients. Ann Surg 1988; 207:373–379.
  • 22
    Yokoyama I, Sheahan G, Carr B, Kakizoe S, Selby R, Tzakis AG, et al. Clinicopathologic factors affecting patient survival and tumor recurrence after orthotopic liver transplantation for hepatocellular carcinoma. Transplant Proc 1991; 23:2194–2196.
  • 23
    Jonas S, Bechstein WO, Steinmuller T, Herrman M, Radke C, Berg T, et al. Vascular invasion and histologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 2001; 33:1080–1086.
    Direct Link:
  • 24
    Takamori R, Wong LL, Dang C, Wong L. Needle-tract implantation from hepatocellular cancer: Is needle biopsy of the liver always necessary? Liver Transpl 2000; 6:67–72.
  • 25
    Wiesner RH, McDiarmid SV, Kamath PS, Edwards EB, Malinchoc M, Kremers WK, et al. MELD and PELD: Application of survival models to liver allocation. Liver Transpl 2001; 7:567–580.
    Direct Link:
  • 26
    Yao FY, Bass NM, Watson J, Davern T, Wu V, Moore B, et al. Liver transplantation for hepatocellular carcinoma—A prospective analysis of survival according to intention-to-treat, and the rate of “drop-out” from the waiting list [abstract]. Hepatology 2001; 34:174A.
  • 27
    Sarasin FP, Majno PE, Llovet JM, Bruix J, Mentha G, Hadengue A. Living donor liver transplantation for early hepatocellular carcinoma: A life-expectancy and cost-effectiveness perspective. Hepatology 2001; 33:1073–1079.
    Direct Link:
  • 28
    Cheng SJ, Pratt DS, Freeman RB, Kaplan MM, Wong JB. Living-donor versus cadaveric liver transplantation for non-resectable small hepatocellular carcinoma and compensated cirrhosis: A decision analysis. Transplantation 2001; 72:861–868.
  • 29
    Bruix J, Llovet JM. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 2002; 35:519–524.
    Direct Link:
Get PDF (112K)