• Please log in or register to access this feature.

Original Article

You have full text access to this OnlineOpen article

Liver transplantation for HCV-associated liver cirrhosis: Predictors of outcomes in a population with significant genotype 3 and 4 distribution

  1. A Zekry1,
  2. P Whiting2,
  3. DH Crawford2,
  4. PW Angus3,
  5. GP Jeffrey4,
  6. RT Padbury5,
  7. EJ Gane6,
  8. GW McCaughan1,*

Article first published online: 30 DEC 2003

DOI: 10.1053/jlts.2003.50063

Issue

Liver Transplantation

Liver Transplantation

Volume 9, Issue 4, pages 339–347, April 2003

Additional Information

How to Cite

Zekry, A., Whiting, P., Crawford, D., Angus, P., Jeffrey, G., Padbury, R., Gane, E. and McCaughan, G. (2003), Liver transplantation for HCV-associated liver cirrhosis: Predictors of outcomes in a population with significant genotype 3 and 4 distribution. Liver Transpl, 9: 339–347. doi: 10.1053/jlts.2003.50063

Author Information

  1. 1

    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney

  2. 2

    Princess Alexandra Hospital, Brisbane; Australia

  3. 3

    Austin and Repatriation Medical Centre, Melbourne; Australia

  4. 4

    Sir Charles Gairdner Hospital, Perth; Australia

  5. 5

    Flinders Medical Center, Adelaide, Australia

  6. 6

    Auckland Hospital, Auckland, New Zealand

*The AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital and University of Sydney, Missenden Rd, Camperdown 2050, Australia. Telephone: 61-29-515-8578; FAX: 61-29-515-5182

Publication History

  1. Issue published online: 30 DEC 2003
  2. Article first published online: 30 DEC 2003

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (108K)

References

  • 1
    Berenguer M, Ferrell L, Watson J, Prieto M, Kim M, Rayon M, et al. HCV-related fibrosis progression following liver transplantation: Increase in recent years. J Hepatol 2000; 32:673–684.
  • 2
    Prieto M, Berenguer M, Rayon JM, Cordoba J, Arguello L, Carrasco D, et al. High incidence of allograft cirrhosis in hepatitis C virus genotype 1b infection following transplantation: Relationship with rejection episodes. Hepatology 1999; 29:250–256.
    Direct Link:
  • 3
    Charlton M, Seaberg E, Wiesner R, Everhart J, Zetterman R, Lake J, et al. Predictors of patient and graft survival following liver transplantation for hepatitis C. Hepatology 1998; 28:823–830.
    Direct Link:
  • 4
    Rosen HR, Gretch DR, Oehlke M, Flora KD, Benner KG, Rabkin JM, et al. Timing and severity of initial hepatitis C recurrence as predictors of long-term liver allograft injury. Transplantation 1998; 65:1178–1182.
  • 5
    Feray C, Caccamo L, Alexander GJ, Ducot B, Gugenheim J, Casanovas T, et al. European collaborative study on factors influencing outcome after liver transplantation for hepatitis C. European Concerted Action on Viral Hepatitis (EUROHEP) Group. Gastroenterology 1999; 117:619–625.
  • 6
    Berenguer M, Prieto M, Cordoba J, Rayon JM, Carrasco D, Olaso V, et al. Early development of chronic active hepatitis in recurrent hepatitis C virus infection after liver transplantation: association with treatment of rejection. J Hepatol 1998; 28:756–763.
  • 7
    Rosen HR, Shackleton CR, Higa L, Gralnek IM, Farmer DA, McDiarmid SV, et al. Use of OKT3 is associated with early and severe recurrence of hepatitis C after liver transplantation. Am J Gastroenterol 1997; 92:1453–1457.
  • 8
    Feray C, Gigou M, Samuel D, Paradis V, Mishiro S, Maertens G, et al. Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation. Gastroenterology 1995; 108:1088–1096.
  • 9
    Gane EJ, Portmann BC, Naoumov NV, Smith HM, Underhill JA, Maertens G, et al. Long-term outcome of hepatitis C infection after liver transplantation. N Engl J Med 1996; 334:815–820.
  • 10
    Zhou S, Terrault NA, Ferrell L, Hahn JA, Lau JY, Simmonds P, et al. Severity of liver disease in liver transplantation recipients with hepatitis C virus infection: Relationship to genotype and level of viremia. Hepatology 1996; 24:1041–1046.
    Direct Link:
  • 11
    Berenguer M, Prieto M, San Juan F, Rayon JM, Martinez F, Carrasco D, et al. Contribution of donor age to the recent decrease in patient survival among HCV-infected liver transplant recipients. Hepatology 2002; 36:202–210.
    Direct Link:
  • 12
    Busquets J, Xiol X, Figueras J, Jaurrieta E, Torras J, Ramos E, et al. The impact of donor age on liver transplantation: Influence of donor age on early liver function and on subsequent patient and graft survival. Transplantation 2001; 71:1765–1771.
  • 13
    Burak KW, Kremers WK, Batts KP, Wiesner RH, Rosen CB, Razonable RR, et al. Impact of cytomegalovirus infection, year of transplantation, and donor age on outcomes after liver transplantation for hepatitis C. Liver Transpl 2002; 8:362–369.
    Direct Link:
  • 14
    Chen J, McGuinness PH, Koorey DJ, Rickard K, Wylie B, McCaughan GW. Hepatitis C virus genotypes in a cohort of Australian blood donors and haemophiliac and liver transplant patients. J Gastro Hepatol 1997; 12:182–187.
    Direct Link:
  • 15
    McGuinness PH, Bishop GA, Painter DM, Chan R, McCaughan GW. Intrahepatic hepatitis C RNA levels do not correlate with degree of liver injury in patients with chronic hepatitis C. Hepatology 1996; 23:676–687.
    Direct Link:
  • 16
    Gayowski T, Singh N, Marino IR, Vargas H, Wagener M, Wannstedt C, et al. Hepatitis C virus genotypes in liver transplant recipients: impact on posttransplant recurrence, infections, response to interferon-alpha therapy and outcome. Transplantation 1997; 64:422–426.
  • 17
    Bukh J, Miller RH, Purcell RH. Genetic heterogeneity of hepatitis C virus: Quasispecies and genotypes. Semin Liver Dis 1995; 15:41–63.
  • 18
    Argentini C, Dettori S, Villano U, Guadagnino V, Infantolino D, Dentico P, et al. Molecular characterisation of HCV genotype 4 isolates circulating in Italy. J Med Virol 2000; 62:84–90.
    Direct Link:
  • 19
    Khan MH, Farrell GC, Byth K, Lin R, Weltman M, George J, et al. Which patients with hepatitis C develop liver complications? Hepatology 2000; 31:513–520.
    Direct Link:
  • 20
    Zylberberg H, Chaix ML, Brechot C. Infection with hepatitis C virus genotype 4 is associated with a poor response to interferon-alpha. Ann Intern Med 2000; 132:845–846.
  • 21
    Ray SC, Arthur RR, Carella A, Bukh J, Thomas DL. Genetic epidemiology of hepatitis C virus throughout Egypt. J Infect Dis 2000; 182:698–707.
  • 22
    Deschenes M, Forbes C, Tchervenkov J, Barkun J, Metrakos P, Tector J, et al. Use of older donor livers is associated with more extensive ischemic damage on intraoperative biopsies during liver transplantation. Liver Transpl Surg 1999; 5:357–361.
    Direct Link:
  • 23
    Burra P, Mioni D, Cecchetto A, Cillo U, Zanus G, Fagiuoli S, et al. Histological features after liver transplantation in alcoholic cirrhotics. J Hepatol 2001; 34:716–722.
  • 24
    Bellamy CO, DiMartini AM, Ruppert K, Jain A, Dodson F, Torbenson M, et al. Liver transplantation for alcoholic cirrhosis: Long-term follow-up and impact of disease recurrence. Transplantation 2001; 72:619–626.
  • 25
    Pera M, Garcia-Valdecasas JC, Grande L, Rimola A, Fuster J, Lacy AM, et al. Liver transplantation for alcoholic cirrhosis with anti-HCV antibodies. Transpl Int 1997; 10:289–292.
    Direct Link:
Get PDF (108K)