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Liver transplantation for primary sclerosing cholangitis in the Nordic countries: Outcome after acceptance to the waiting list

  1. Bjørn Brandsæter1,*,
  2. Ulrika Broomé2,
  3. Helena Isoniemi3,
  4. Styrbjörn Friman4,
  5. Bent Hansen5,
  6. Erik Schrumpf1,
  7. Antti Oksanen2,
  8. Bo-Göran Ericzon7,
  9. Krister Höckerstedt3,
  10. Heikki Mäkisalo3,
  11. Rolf Olsson8,
  12. Michael Olausson4,
  13. Preben Kirkegaard6,
  14. Kristian Bjøro1

Article first published online: 30 DEC 2003

DOI: 10.1053/jlts.2003.50169

Issue

Liver Transplantation

Liver Transplantation

Volume 9, Issue 9, pages 961–969, September 2003

Additional Information

How to Cite

Brandsæter, B., Broomé, U., Isoniemi, H., Friman, S., Hansen, B., Schrumpf, E., Oksanen, A., Ericzon, B.-G., Höckerstedt, K., Mäkisalo, H., Olsson, R., Olausson, M., Kirkegaard, P. and Bjøro, K. (2003), Liver transplantation for primary sclerosing cholangitis in the Nordic countries: Outcome after acceptance to the waiting list. Liver Transpl, 9: 961–969. doi: 10.1053/jlts.2003.50169

Author Information

  1. 1

    Department of Medicine, Rikshospitalet, Oslo, Norway, Sahlgrenska Hospital, Gothenburg, Sweden

  2. 2

    Department of Gastroenterology and Hepatology, Huddinge University Hospital, Stockholm, Sweden

  3. 3

    Department of Transplantation and Liver Surgery, University Hospital, Helsinki, Finland

  4. 4

    Department of Transplantation Surgery, Sahlgrenska Hospital, Gothenburg, Sweden

  5. 5

    Department of Hepatology, Rigshospitalet, Copenhagen, Denmark

  6. 6

    Department of Transplantation Surgery, Rigshospitalet, Copenhagen, Denmark

  7. 7

    Department of Transplantation and Liver Surgery, Huddinge University Hospital, Stockholm, Sweden

  8. 8

    Department of Medicine, Sahlgrenska Hospital, Gothenburg, Sweden

*Section of Hepatology and Gastroenterology, Department of Medicine, Rikshospitalet, 0027 Oslo, Norway. Telephone: 47-23072462; FAX: 47-23070451

Publication History

  1. Issue published online: 30 DEC 2003
  2. Article first published online: 30 DEC 2003

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Abstract

Primary sclerosing cholangitis (PSC) is a common indication for liver transplantation, but evaluation of patients and timing of liver transplantation remain as major problems. Data from PSC and control patients listed for liver transplantation from 1990 through 2000 in the Nordic countries were recorded prospectively. Outcomes from the waiting list and after transplantation have been recorded for both groups. For PSC patients, regression analyses have been performed to analyze predictors of outcome. A total of 255 PSC and 610 control patients were accepted on the liver transplantation waiting list from 1990 to 2000. In the PSC group, 223 patients (87%) received a first liver allograft, and 32 patients (13%) died without transplantation. The corresponding figures for the control group were 89% and 10%. For PSC patients, the 5- and 10-year survival from the time of acceptance was 68% and 58%, respectively. A higher Model for End-Stage Liver Disease score and a shorter duration of PSC predicted death on the waiting list for PSC patients. PSC is a frequent indication for liver transplantation. In our material, serum bilirubin or Model for End-Stage Liver Disease score and PSC duration are predictors of outcome including survival of the waiting list.

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