Liver Transplantation And Hepatitis C: A Single Topic And Consensus Development Symposium
The natural history and outcome of liver transplantation in hepatitis C virus-infected recipients
Article first published online: 30 DEC 2003
Copyright © 2003 American Association for the Study of Liver Diseases
Volume 9, Issue 11, pages S28–S34, November 2003
How to Cite
Gane, E. (2003), The natural history and outcome of liver transplantation in hepatitis C virus-infected recipients. Liver Transpl, 9: S28–S34. doi: 10.1053/jlts.2003.50248
- Issue published online: 30 DEC 2003
- Article first published online: 30 DEC 2003
1. Recurrence of hepatitis C infection is universal and immediate after liver transplantation.
2. Graft and patient survival is reduced in liver transplantation recipients with recurrent hepatitis C virus infection compared with hepatitis C virus-negative recipients.
3. The natural history of chronic hepatitis C is accelerated after liver transplantation compared with nontransplantation chronic hepatitis C; 20% to 40% of patients progress to allograft cirrhosis within 5 years, compared with less than 5% of nontransplantation patients.
4. The rate of fibrosis progression is not uniform and may change over time.
5. The rate of progression from cirrhosis to decompensation is accelerated after liver transplantation. The rate of decompensation is >40% at 1 year and >60% at 3 years, compared with <5% and <10%, respectively, in immunocompetent patients.
6. The rate of progression from decompensation to death is also accelerated after liver transplantation. The 3-year survival is <10% after the onset of hepatitis C virus-related allograft failure, compared with 60% after decompensation in immunocompetent patients.