Bone mineral density is reduced in brain tumour patients treated in childhood
Article first published online: 29 MAR 2007
Volume 95, Issue 10, pages 1291–1297, October 2006
How to Cite
Pietilä, S., Sievänen, H., Ala-Houhala, M., Koivisto, A.-M., Lenko, H. L. and Mäkipernaa, A. (2006), Bone mineral density is reduced in brain tumour patients treated in childhood. Acta Paediatrica, 95: 1291–1297. doi: 10.1080/08035250600586484
- Issue published online: 29 MAR 2007
- Article first published online: 29 MAR 2007
- (Received 28 January 2005; revised 9 December 2005; accepted 20 January 2006)
- Bone mineral density;
- brain tumour;
Aim: To determine the prevalence of low bone mineral density among children surviving brain tumours and to identify possible factors underlying impaired bone health. Methods: Cross-sectional study; total body bone mineral density (TBBMD), fat mass (FM) and lean body mass (LBM) were measured by dual-energy X-ray absorptiometry (DXA) in 46 brain tumour patients aged from 3.8 to 28.7 y (mean 14.9 y) treated in childhood 1.4–14.8 y (mean 6.4 y) after end of treatment for brain tumour. Low bone mineral density was defined as TBBMD z score<−2.0. Results: Fifteen patients had TBBMD z scores<−2.0, indicating a 33% prevalence of low bone density. The TBBMD z score ranged from −5.7 to 0.6 (mean −1.7). Out of several potential factors, only combined craniospinal irradiation was significantly associated with low z score (p=0.034, according to multiple regression analysis), while exclusive cranial irradiation showed a borderline statistical association (p=0.100, according to multiple regression analysis).
Conclusion: One third of brain tumour patients treated in childhood had reduced bone mineral density. The reasons for this condition are apparently multifactorial, including craniospinal irradiation.