Platelet Adhesion under Flow
Article first published online: 26 JAN 2010
Volume 16, Issue 1, pages 58–83, January 2009
How to Cite
RUGGERI, Z. M. (2009), Platelet Adhesion under Flow. Microcirculation, 16: 58–83. doi: 10.1080/10739680802651477
- Issue published online: 26 JAN 2010
- Article first published online: 26 JAN 2010
- Received 17 July 2008; accepted 27 November 2008.
- vascular biology;
- extracellular matrix;
Platelet-adhesive mechanisms play a well-defined role in hemostasis and thrombosis, but evidence continues to emerge for a relevant contribution to other pathophysiological processes, including inflammation, immune-mediated responses to microbial and viral pathogens, and cancer metastasis. Hemostasis and thrombosis are related aspects of the response to vascular injury, but the former protects from bleeding after trauma, while the latter is a disease mechanism. In either situation, adhesive interactions mediated by specific membrane receptors support the initial attachment of single platelets to cellular and extracellular matrix constituents of the vessel wall and tissues. In the subsequent steps of thrombus growth and stabilization, adhesive interactions mediate platelet-to-platelet cohesion (i.e., aggregation) and anchoring to the fibrin clot. A key functional aspect of platelets is their ability to circulate in a quiescent state surveying the integrity of the inner vascular surface, coupled to a prompt reaction wherever alterations are detected. In many respects, therefore, platelet adhesion to vascular wall structures, to one another, or to other blood cells are facets of the same fundamental biological process. The adaptation of platelet-adhesive functions to the effects of blood flow is the main focus of this review.