CD34 is a Key Regulator of Hematopoietic Stem Cell Trafficking to Bone Marrow and Mast Cell Progenitor Trafficking in the Periphery
Article first published online: 26 JAN 2010
Volume 16, Issue 6, pages 487–496, August 2009
How to Cite
NIELSEN, J. S. and MCNAGNY, K. M. (2009), CD34 is a Key Regulator of Hematopoietic Stem Cell Trafficking to Bone Marrow and Mast Cell Progenitor Trafficking in the Periphery. Microcirculation, 16: 487–496. doi: 10.1080/10739680902941737
- Issue published online: 26 JAN 2010
- Article first published online: 26 JAN 2010
- Received 20 January 2009; accepted 2 April 2009.
- hematopoietic stem cell;
- mast cell;
CD34 is a cell-surface sialomucin widely used for hematopoietic stem cell purification and as a marker of most vascular endothelial cells, including those of capillaries in the majority of tissues. Surprisingly, despite extensive research, the function of this sialomucin has remained elusive, with proposed roles ranging from enhancing proliferation or inhibiting differentiation to acting as a proadhesive L-selectin ligand. Here, we review our recent studies, which suggest that CD34 does, indeed, play a role in leukocyte and HSC trafficking, but that this is through its action as a regulated blocker of cell adhesion and enhancer of migration.