Antimicrobial treatment of H. pylori infection—a pooled efficacy analysis of eradication therapies
Article first published online: 27 NOV 2003
Copyright © 1998 Taylor and Francis Ltd
European Journal of Surgery
Volume 164, Issue S12, pages 16–26, December 1998
How to Cite
Unge, P. (1998), Antimicrobial treatment of H. pylori infection—a pooled efficacy analysis of eradication therapies. Eur J Surg, 164: 16–26. doi: 10.1080/11024159850191391
- Issue published online: 27 NOV 2003
- Article first published online: 27 NOV 2003
- Cited By
To evaluate the clinical efficacy of available therapies directed towards Helicobacter pylori eradication.
Pooled overall analyses of a limited number of drug combinations regardless of dosage, duration, formulation etc.
Helicobacter pylori infected patients with or without complications.
Efficacy data from all studies included in the analysis are transformed to or retained as intention to treat data.
Efficacy is presented as proportion of patients cured from the infection. Confidence intervals are enlarged by 1.5 due to the inferior strength of a pooled analysis.
Dual therapies are ineffective. Triple therapies cure 70–90% of the patients. Well documented high efficacy is shown for a proton pump inhibitor plus two antimicrobials. Less studied but effective alternatives are ranitidine-bismuth plus two antimicrobials.
A proton pump inhibitor plus two antimicrobials is the best validated highly effective type of eradication therapy. Copyright © 1998 Taylor and Francis Ltd.