Antimicrobial treatment of H. pylori infection—a pooled efficacy analysis of eradication therapies

Authors

  • Peter Unge


Abstract

Objective:

To evaluate the clinical efficacy of available therapies directed towards Helicobacter pylori eradication.

Design:

Pooled overall analyses of a limited number of drug combinations regardless of dosage, duration, formulation etc.

Subjects:

Helicobacter pylori infected patients with or without complications.

Interventions:

Efficacy data from all studies included in the analysis are transformed to or retained as intention to treat data.

Main outcome:

Efficacy is presented as proportion of patients cured from the infection. Confidence intervals are enlarged by 1.5 due to the inferior strength of a pooled analysis.

Results:

Dual therapies are ineffective. Triple therapies cure 70–90% of the patients. Well documented high efficacy is shown for a proton pump inhibitor plus two antimicrobials. Less studied but effective alternatives are ranitidine-bismuth plus two antimicrobials.

Conclusion:

A proton pump inhibitor plus two antimicrobials is the best validated highly effective type of eradication therapy. Copyright © 1998 Taylor and Francis Ltd.

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