SEARCH

SEARCH BY CITATION

Keywords:

  • Adenylyl cyclase;
  • cAMP;
  • bicarbonate;
  • prokaryote;
  • signal transduction

Abstract

Bicarbonate ion is fundamental to the biology of all living organisms. HCO3- is vital to such diverse physiological processes as carbon fixation, cellular homeostasis, sperm maturation, and nucleotide synthesis. A defined subset of adenylyl cyclases identified in eukaryotes and prokaryotes are directly activated by HCO3-. As such, cAMP represents the first identified biological effector for fluctuations in intracellular inorganic carbon levels. The identification of a signal transduction pathway activated by HCO3- has far reaching implications for understanding how the cell responds to fluctuations in this essential anion. IUBMB Life, 56: 529-534, 2004