Evidence for antiradical and antioxidant properties of four biologically active N,N-Diethylaminoethyl ethers of flavaone oximes: A comparison with natural polyphenolic flavonoid rutin action

Authors

  • Diana Metodiewa,

    Corresponding author
    1. Institute of Applied Radiation Chemistry, Technical University of Łódź, Wróblewskiego 15, 93-590 Łódź, Poland
    • Fax: (48-42) 36-02-46, E-mail: media@mitr.p.lodzpl
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  • Agata Kochman,

    1. Department of Pathological Anatomy, Medical University of Wrocław, Marcinkowskiego 1, 50-368 Wrocław, Poland
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  • Stefan Karolczak

    1. Institute of Applied Radiation Chemistry, Technical University of Łódź, Wróblewskiego 15, 93-590 Łódź, Poland
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Abstract

The antiradical and antioxidant activities of four biologically active N,N-diethyloaminoethyl ethers of flavanone oximes (N,N-DEAEFo) were investigated in vitro and compared with these of polyphenolic flavonoid (rutin). Four experimental models were used: iron- and ascorbate driven Fenton systems, γ-radiolysis, xanthine/xanthine oxidase system and diphenylpicrylhydrazyl (DPPH) radical scavenging. The results clearly indicate that N,N-DEAEFo are acting as promising antioxidants and radioprotectors comparable to rutin activities: they should prove to be useful under acute oxidative stress conditions for which both properties were required.

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