SEARCH

SEARCH BY CITATION

References

  • Ahmed SA and Sriranganathan N (1994) Differential effects of dexamethasone on the thymus and spleen: alterations in programmed cell death, lymphocyte subsets and activation of T cells. Immunopharmacology, 28, 5566.
  • Alessi DR and Cohen P (1998) Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev, 8, 5562.
  • Araki E, Lipes MA, Patti ME, Bruning JC, Haag B, III Johnson, RS and Kahn CR (1994) Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature, 372, 186190.
  • Baker J, Liu JP, Robertson EJ and Efstratiadis A (1993) Role of insulin-like growth factors in embryonic and postnatal growth. Cell, 75, 7382.
  • Bi L, Okabe I, Bernard DJ, Wynshaw-Boris A and Nussbaum RL (1999) Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase. J Biol Chem, 274, 1096310968.
  • Bogoyevitch MA, Glennon PE, Andersson MB, Clerk A, Lazou A, Marshall CJ, Parker PJ and Sugden PH (1994) Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy. J Biol Chem, 269, 11101119.
  • Bohni R, Riesgo-Escovar J, Oldham S, Brogiolo W, Stocker H, Andruss BF, Beckingham K and Hafen E (1999) Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell, 97, 865875.
  • Boluyt MO, Zheng JS, Younes A, Long X, O'Neill L, Silverman H, Lakatta EG and Crow MT (1997) Rapamycin inhibits α1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase. Circ Res, 81, 176186.
  • Brunet A et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 96, 857868.
  • Burgering BM and Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature, 376, 599602.
  • Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S and Reed JC (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science, 282, 13181321.
  • Chan TO, Rittenhouse SE and Tsichlis PN (1999) Akt/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem, 68, 9651014.
  • Chien KR, Knowlton KU, Zhu H and Chien S (1991) Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J, 5, 30373046.
  • Chien KR, Grace AA and Hunter JJ (1998) Molecular biology of cardiac hypertrophy and heart failure. In Chein,K.R. (ed.), Molecular Basis of Cardiovascular Disease W.B.Saunders Co., Philadelphia, PA, pp. 211250.
  • Chou MM and Blenis J (1995) The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. Curr Opin Cell Biol, 7, 806814.
  • Conlon I and Raff M (1999) Size control in animal development. Cell, 96, 235244.
  • Conus NM, Hemmings BA and Pearson RB (1998) Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k. J Biol Chem, 273, 47764782.
  • Coolican SA, Samuel DS, Ewton DZ, McWade FJ and Florini JR (1997) The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways. J Biol Chem, 272, 66536662.
  • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91, 231241.
  • DeChiara TM, Efstratiadis A and Robertson EJ (1990) A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature, 345, 7880.
  • Dhand R et al. (1994) PI 3-kinase: structural and functional analysis of intersubunit interactions. EMBO J, 13, 511521.
  • Donath MY, Gosteli-Peter MA, Hauri C, Froesch ER and Zapf J (1997) Insulin-like growth factor-I stimulates myofibrillar genes and modulates atrial natriuretic factor mRNA in rat heart. Eur J Endocrinol, 137, 309315.
  • Downward J (1998) Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol, 10, 262267.
  • Duckworth BC and Cantley LC (1997) Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength. J Biol Chem, 272, 2766527670.
  • Dufner A, Andjelkovic M, Burgering BM, Hemmings BA and Thomas G (1999) Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation. Mol Cell Biol, 19, 45254534.
  • Eppenberger-Eberhardt M, Aigner S, Donath MY, Kurer V, Walther P, Zuppinger C, Schaub MC and Eppenberger HM (1997) IGF-I and bFGF differentially influence atrial natriuretic factor and α-smooth muscle actin expression in cultured atrial compared to ventricular adult rat cardiomyocytes. J Mol Cell Cardiol, 29, 20272039.
  • Ernsberger P, Koletsky RJ, Baskin JS and Collins LA (1996) Consequences of weight cycling in obese spontaneously hypertensive rats. Am J Physiol, 270, R864R872.
  • Fentzke RC, Korcarz CE, Lang RM, Lin H and Leiden JM (1998) Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. J Clin Invest, 101, 24152426.
  • Foncea R, Andersson M, Ketterman A, Blakesley V, Sapag-Hagar M, Sugden PH, LeRoith D and Lavandero S (1997) Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes. J Biol Chem, 272, 1911519124.
  • Franke TF, Kaplan DR and Cantley LC (1997a) PI3K: downstream AKTion blocks apoptosis. Cell, 88, 435437.
  • Franke TF, Kaplan DR, Cantley LC and Toker A (1997b) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science, 275, 665668.
  • Frisch SM and Francis H (1994) Disruption of epithelial cell–matrix interactions induces apoptosis. J Cell Biol, 124, 619626.
  • Fruman DA, Meyers RE and Cantley LC (1998) Phosphoinositide kinases. Annu Rev Biochem, 67, 481507.
  • Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW and Cantley LC (1999) Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science, 283, 393397.
  • Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N and Hay N (1998) 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev, 12, 502513.
  • Goodman MN, Lowell B, Belur E and Ruderman NB (1984) Sites of protein conservation and loss during starvation: influence of adiposity. Am J Physiol, 246, E383E390.
  • Gulick J, Subramaniam A, Neumann J and Robbins J (1991) Isolation and characterization of the mouse cardiac myosin heavy chain genes. J Biol Chem, 266, 91809185.
  • Hayashi K, Saga H, Chimori Y, Kimura K, Yamanaka Y and Sobue K (1998) Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and phosphatidylinositol 3-kinase. J Biol Chem, 273, 2886028867.
  • Hu Q, Klippel A, Muslin AJ, Fantl WJ and Williams LT (1995) Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science, 268, 100102.
  • Izumo S and Shioi T (1998) Cardiac transgenic and gene-targeted mice as models of cardiac hypertrophy and failure: a problem of (new) riches. J Card Fail, 4, 263270.
  • Izumo S, Nadal-Ginard B and Mahdavi V (1988) Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci USA, 85, 339343.
  • Jiang BH, Aoki M, Zheng JZ, Li J and Vogt PK (1999) Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B. Proc Natl Acad Sci USA, 96, 20772081.
  • Kadambi VJ and Kranias EG (1998) Genetically engineered mice: model systems for left ventricular failure. J Card Fail, 4, 349361.
  • Kimball SR, Shantz LM, Horetsky RL and Jefferson LS (1999) Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. J Biol Chem, 274, 1164711652.
  • Klippel A, Escobedo JA, Hirano M and Williams LT (1994) The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol Cell Biol, 14, 26752685.
  • Klippel A, Reinhard C, Kavanaugh WM, Apell G, Escobedo MA and Williams LT (1996) Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol Cell Biol, 16, 41174127.
  • Leevers SJ, Weinkove D, MacDougall LK, Hafen E and Waterfield MD (1996) The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J, 15, 65846594.
  • Li Q, Li B, Wang X, Leri A, Jana KP, Liu Y, Kajstura J, Baserga R and Anversa P (1997) Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest, 100, 19911999.
  • Liu JP, Baker J, Perkins AS, Robertson EJ and Efstratiadis A (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell, 75, 5972.
  • Manning WJ, Wei JY, Katz SE, Litwin SE and Douglas PS (1994) In vivo assessment of LV mass in mice using high-frequency cardiac ultrasound: necropsy validation. Am J Physiol, 266, H1672H1675.
  • Martin SS, Haruta T, Morris AJ, Klippel A, Williams LT and Olefsky JM (1996) Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem, 271, 1760517608.
  • Miklos GL and Rubin GM (1996) The role of the genome project in determining gene function: insights from model organisms. Cell, 86, 521529.
  • Montagne J, Stewart MJ, Stocker H, Hafen E, Kozuma SC and Thomas G (1999) Drosophila S6 kinase: a regulator of cell size. Science, 285, 21262129.
  • Ng WA, Grupp IL, Subramaniam A and Robbins J (1991) Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart. Circ Res, 68, 17421750.
  • Palermo J, Gulick J, Colbert M, Fewell J and Robbins J (1996) Transgenic remodeling of the contractile apparatus in the mammalian heart. Circ Res, 78, 504509.
  • Rameh LE and Cantley LC (1999) The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem, 274, 83478350.
  • Sadoshima J and Izumo S (1995) Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy. Circ Res, 77, 10401052.
  • Sadoshima J and Izumo S (1997) The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol, 59, 551571.
  • Sahn DJ, DeMaria A, Kisslo J and Weyman A (1978) Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation, 58, 10721083.
  • Serunian LA, Auger KR and Cantley LC (1991) Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation. Methods Enzymol, 198, 7887.
  • Shima H, Pende M, Chen Y, Fumagalli S, Thomas G and Kozma SC (1998) Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J, 17, 66496659.
  • Soonpaa MH and Field LJ (1998) Survey of studies examining mammalian cardiomyocyte DNA synthesis. Circ Res, 83, 1526.
  • Soonpaa MH, Kim KK, Pajak L, Franklin M and Field LJ (1996) Cardiomyocyte DNA synthesis and binucleation during murine development. Am J Physiol, 271, H2183H2189.
  • Soonpaa MH, Koh GY, Pajak L, Jing S, Wang H, Franklin MT, Kim KK and Field LJ (1997) Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest, 99, 26442654.
  • Sugden PH and Clerk A (1998) Cellular mechanisms of cardiac hypertrophy. J Mol Med, 76, 725746.
  • Takata M et al. (1999) Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1). J Biol Chem, 274, 2061120618.
  • Tamemoto H et al. (1994) Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature, 372, 182186.
  • Thomas G and Hall MN (1997) TOR signalling and control of cell growth. Curr Opin Cell Biol, 9, 782787.
  • Toker A and Cantley LC (1997) Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature, 387, 673676.
  • Vanhaesebroeck B, Leevers SJ, Panayotou G and Waterfield MD (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci, 22, 267272.
  • Verdu J, Buratovich MA, Wilder EL and Birnbaum MJ (1999) Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nature Cell Biol, 1, 500506.
  • Wakasaki H, Koya D, Schoen FJ, Jirousek MR, Ways DK, Hoit BD, Walsh RA and King GL (1997) Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci USA, 94, 93209325.
  • Wang L, Ma W, Markovich R, Chen JW and Wang PH (1998) Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I. Circ Res, 83, 516522.
  • Weinkove D, Neufeld TP, Twardzik T, Waterfield MD and Leevers SJ (1999) Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. Curr Biol, 9, 10191029.
  • Weng QP, Kozlowski M, Belham C, Zhang A, Comb MJ and Avruch J (1998) Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. J Biol Chem, 273, 1662116629.
  • Withers DJ et al. (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature, 391, 900904.
  • Wolska BM and Solaro RJ (1996) Method for isolation of adult mouse cardiac myocytes for studies of contraction and microfluorimetry. Am J Physiol, 271, H1250H1255.
  • Yoshizumi M et al. (1995) Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts. J Clin Invest, 95, 22752280.
  • Yu J, Zhang Y, McIlroy J, Rordorf-Nikolic T, Orr GA and Backer JM (1998) Regulation of the p85/p110 phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit. Mol Cell Biol, 18, 13791387.