Presented at the Meeting of the Middle Section of the American Laryngological, Rhinological and Otological Society, Inc., Kansas City, January 26, 1997.
Version of Record online: 4 JAN 2009
Copyright © 1998 The Triological Society
Volume 108, Issue 1, pages 26–31, January 1998
How to Cite
Krenning, J., Hughes, L. F., Caspary, D. M. and Helfert, R. H. (1998), Age-Related Glycine Receptor Subunit Changes in the Cochlear Nucleus of Fischer-344 Rats. The Laryngoscope, 108: 26–31. doi: 10.1097/00005537-199801000-00005
This research was supported by a grant from the American Laryngological, Rhinological and Otological Society to J.K., and United States Public Health Service grant DC-02247.
- Issue online: 4 JAN 2009
- Version of Record online: 4 JAN 2009
Previous studies have shown that levels of binding for the strychnine-sensitive glycine receptor in the cochlear nucleus (CN) of Fischer(F344) rats decrease with age. Given the major role glycine plays in normal CN function, changes in glycine-receptor activity may contribute to central presbycusis. To further evaluate the impact of age on glycine receptors, in situ hybridization was used to assess, in three age groups of F344 rats, changes in levels of gene expression for four of its subunits. When compared with the 3-month-old rats, expression of mRNAs for α1 and β subunits in the anteroventral CN decreased significantly in the 18- and 27-month-old age groups, while mRNA expression for the α2 subunit increased. If protein expressions are similar, these subunit changes may alter the function of glycine receptors, thereby affecting binding to its ligands.