Presented at 27th Turk Ulusal Otorinolarengoloji Bas Boyun Cerrahisi Kongresi (The Congress of 27th Turkish National Otorhinolaryngology Head Neck Surgery), Turk Otorinolarengoloji Bas Boyun Cerrahisi Dernegi (Turkish Otorhinolaryngology Head Neck Surgery Society), Antalya, Turkey, October 4–9, 2003.
Role of Free Radicals and Antioxidants in Nasal Polyps†
Article first published online: 3 JAN 2009
Copyright © 2004 The Triological Society
Volume 114, Issue 7, pages 1200–1203, July 2004
How to Cite
Dagli, M., Eryilmaz, A., Besler, T., Akmansu, H., Acar, A. and Korkmaz, H. (2004), Role of Free Radicals and Antioxidants in Nasal Polyps. The Laryngoscope, 114: 1200–1203. doi: 10.1097/00005537-200407000-00013
This research was funded by the Scientific Research Fund of Hacettepe University (Project No: 0102402002 and 0102402004).
- Issue published online: 3 JAN 2009
- Article first published online: 3 JAN 2009
- Manuscript Accepted: 15 JAN 2004
- Free radicals;
- oxidative stress;
- nasal polyp
Objectives/Hypothesis: The aim of this study is to determine the role of free radicals and antioxidants in nasal polyps.
Study Design: Prospective, randomized, controlled study.
Methods: Thirty-one patients with nasal polyposis and a control group consisting of 19 patients with septal deviation and lower turbinate hypertrophy were included in the study. Levels of the antioxidants retinol, β-carotene, α-tocopherol, and ascorbic acid were measured from the sera of the patients with nasal polyposis and the control group. Plasma levels of superoxide dismutase activity (SOD), glutathione peroxidase (GSHPX) activity, and reduced glutathione (GSH) were also obtained. As a peroxidation product, the levels of the malondialdehyde-thiobarbituric acid (MDA) combination were measured from the plasma of patient and control groups. Measurements of MDA, GSH, and α-tocopherol levels were also taken from the polyp tissue and turbinate mucosa of the control group.
Results: The blood levels of antioxidants and MDA as an oxidant were significantly different in the patient group compared with the control group (P < .01). The tissue levels of antioxidants and MDA were significantly different in the patients with polyposis compared with the control group (P < .01). The blood and tissue anti-oxidant levels were found to be decreased, and MDA levels as an oxidant increased significantly in the patient group with polyposis when compared with the control group, and there was a negative correlation between oxidative stress and antioxidants.
Conclusion: This study demonstrates that oxidative stress and tissue and blood antioxidants in the patients with polyposis were significantly different compared with the control group. The blood and tissue antioxidant levels decreased, and MDA levels, as an oxidant, increased significantly in the patient group with polyposis when compared with the control group. The current study demonstrates that there is strong evidence related to oxidative stress in the pathogenesis of nasal polyposis, and antioxidants can have a preventive role in free–radical-mediated tissue damage in nasal polyposis.