The pathogenicity of cytomegalovirus in inflammatory bowel disease. A systematic review and evidence-based recommendations for future research
Version of Record online: 14 DEC 2006
Copyright © 2004 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 10, Issue 3, pages 245–250, May 2004
How to Cite
Hommes, D. W., Sterringa, G., van Deventer, S. J. H., Tytgat, G. N. J. and Weel, J. (2004), The pathogenicity of cytomegalovirus in inflammatory bowel disease. A systematic review and evidence-based recommendations for future research. Inflamm Bowel Dis, 10: 245–250. doi: 10.1097/00054725-200405000-00011
- Issue online: 14 DEC 2006
- Version of Record online: 14 DEC 2006
- Manuscript Accepted: 25 AUG 2003
- Manuscript Received: 10 MAR 2003
- critical appraisal;
- Crohn's disease;
- ulcerative colitis
During recent years, a clear association between complicated courses of ulcerative colitis and the presence of cytomegalovirus (CMV) has been established. The exact pathogenic role of CMV in these patients remains unclear despite a great number of published reports. Therefore, we undertook a systematic review to appraise critically all available evidence ìn the literature on the role of CMV during inflammatory bowel disease. We identified and analyzed more than 30 case reports and 9 case series. Based on these results, we propose a model for viral replication during inflammation and provide recommendations for future research.