Supported by Indiana University's Alcohol Research Center (AA07611).
Subjective Intoxication in Response to Alcohol Challenge: Heritability and Covariation With Personality, Breath Alcohol Level, and Drinking History
Article first published online: 3 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 27, Issue 5, pages 795–803, May 2003
How to Cite
Viken, R. J., Rose, R. J., Morzorati, S. L., Christian, J. C. and Li, T.-K. (2003), Subjective Intoxication in Response to Alcohol Challenge: Heritability and Covariation With Personality, Breath Alcohol Level, and Drinking History. Alcoholism: Clinical and Experimental Research, 27: 795–803. doi: 10.1097/01.ALC.0000067974.41160.95
- Issue published online: 3 MAY 2006
- Article first published online: 3 MAY 2006
- Received for publication July 18, 2002; accepted February 25, 2003.
- Subjective Intoxication;
Background: Numerous studies have identified differences in subjective response to alcohol in subjects differentiated by family history of alcoholism. Results suggest that genetic influences on individual variation in subjective response to alcohol may be a mechanism for genetic effects on alcohol problems. However, direct evidence for genetic effects on subjective response to alcohol is very limited.
Methods: In a sample of 99 adult twin pairs, we studied genetic influences on subjective intoxication after alcohol challenge. The twins ingested a standard dose of ethanol (0.70 g/kg for men/0.65 g/kg for women), and two measures of subjective response to alcohol were assessed.
Results: Genetic effects on variation in subjective intoxication reported 1 hr after drinking were significant and substantial: heritability was 0.60 for a 22-item scale and 0.48 for a brief 2-item measure. Self-report measures of neuroticism, psychasthenia, hostility, and family problems shared significant genetic covariation with subjective intoxication. Achieved breath alcohol level, rate of change in breath alcohol on the descending limb, and individual drinking history all shared familial variation with subjective intoxication. No significant genetic effects for subjective intoxication were found 2 hr after drinking, but familial influences remained present, and many of the same personality, drinking history, and breath alcohol variables were predictive of intoxication.
Conclusions: Subjective response to alcohol is heritable, and genetic effects on subjective intoxication are partly shared with genetic effects on personality.