Increased Salivary Cortisol Concentrations During Chronic Alcohol Intoxication in a Naturalistic Clinical Sample of Men

Authors

  • Bryon Adinoff,

    Corresponding author
    1. Department of Psychiatry (BA, MJW), University of Texas Southwestern Medical Center, Dallas, Texas; VA North Texas Health Care System (BA, KR), Dallas, Texas; Department of Medicine (AI), University of Virginia, Health Science Center, Charlottesville, Virginia; and VA Medical Center (AI), Salem, Virginia.
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  • Keith Ruether,

    1. Department of Psychiatry (BA, MJW), University of Texas Southwestern Medical Center, Dallas, Texas; VA North Texas Health Care System (BA, KR), Dallas, Texas; Department of Medicine (AI), University of Virginia, Health Science Center, Charlottesville, Virginia; and VA Medical Center (AI), Salem, Virginia.
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  • Steven Krebaum,

    1. Department of Psychiatry (BA, MJW), University of Texas Southwestern Medical Center, Dallas, Texas; VA North Texas Health Care System (BA, KR), Dallas, Texas; Department of Medicine (AI), University of Virginia, Health Science Center, Charlottesville, Virginia; and VA Medical Center (AI), Salem, Virginia.
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  • Ali Iranmanesh,

    1. Department of Psychiatry (BA, MJW), University of Texas Southwestern Medical Center, Dallas, Texas; VA North Texas Health Care System (BA, KR), Dallas, Texas; Department of Medicine (AI), University of Virginia, Health Science Center, Charlottesville, Virginia; and VA Medical Center (AI), Salem, Virginia.
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  • Mark J. Williams

    1. Department of Psychiatry (BA, MJW), University of Texas Southwestern Medical Center, Dallas, Texas; VA North Texas Health Care System (BA, KR), Dallas, Texas; Department of Medicine (AI), University of Virginia, Health Science Center, Charlottesville, Virginia; and VA Medical Center (AI), Salem, Virginia.
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  • Funded by NIAAA Grant AA1570.

Bryon Adinoff, MD, 116A5, Dallas VAMC, 4500 S. Lancaster Rd., Dallas, TX 75216; Fax: 214-857-0902; E-mail: bryon.adinoff@utsouthwestern.edu.

Abstract

Background: Cortisol, the primary glucocorticoid in humans, is intimately involved in the regulation of such varied and critical biological processes as emotion, cognition, reward, immune functioning, and energy utilization. A persistent increase in cortisol concentration as a result of chronic intoxication could therefore result in alcohol-related disorders such as sleep disruption, cognitive deficits, diabetes, and mood disturbances. Although moderate levels of acute alcohol ingestion are reported to produce an increase in cortisol levels, it is uncertain whether cortisol remains persistently increased during long-term chronic intoxication.

Methods: Salivary cortisol and breath alcohol concentrations (BAC) were obtained on 73 subjects with primary alcohol dependence on initial presentation for treatment and 22 alcohol-dependent subjects participating in a residential treatment program.

Results: Both intoxicated alcohol-dependent subjects (n= 38) and nonintoxicated subjects in acute alcohol withdrawal (n= 30) demonstrated significantly increased salivary cortisol concentrations compared with abstinent subjects (n= 27; p < 0.001). Nonintoxicated subjects in acute withdrawal demonstrated significantly increased salivary cortisol concentrations compared with highly intoxicated subjects (BAC >100 mg/dl) but were similar to subjects with lower levels of intoxication (BAC, 10–100 mg/dl).

Conclusions: Chronic alcohol-dependent subjects experience continuously increased concentrations of cortisol during both intoxication and withdrawal. Increased levels of cortisol during chronic intoxication seem to progressively increase with the onset of withdrawal. This suggests a daily cycle of hypercortisolemia during the active drinking phase, with further increases on the cessation of drinking and the emergence of withdrawal symptoms. Persistently increased levels of cortisol may extract a costly allostatic load, resulting in significant central nervous system and peripheral organ morbidity.

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