The Search for Genetic Risk Factors Associated With Suicidal Behavior

Authors

  • Victor Hesselbrock,

    Corresponding author
    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • Danielle Dick,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • Michie Hesselbrock,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • Tatiana Foroud,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • Marc Schuckit,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • Howard Edenberg,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • Kathy Bucholz,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • John Kramer,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • Theodore Reich,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • Alison Goate,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • Laura Bierut,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • John P. Rice,

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • John I. Nurnberger Jr.

    1. Department of Psychiatry (VH), University of Connecticut School of Medicine, Farmington, Connecticut; Department of Psychiatry (DD, TF, HE, JIN), Indiana University School of Medicine, Indianapolis, Indiana; University of Connecticut School of Social Work (MH), W. Hartford, Connecticut; Department of Psychiatry (MS), University of California, San Diego School of Medicine, San Diego, California; Department of Psychiatry (KB, TR, AG, LB, JPR), Washington University School of Medicine, St. Louis, Missouri; and Department of Psychiatry (JK), University of Iowa School of Medicine, Iowa City, Iowa.
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  • Supported by National Institutes of Health Grants U10AA08403, AA03510, AA13358, AA00285, and MO1 RR6192.

Reprint requests: Victor M. Hesselbrock, PhD, Department of Psychiatry, MC-2103, University of Connecticut School of Medicine, Farmington, CT 06030-2103; Fax: 860-679-4077; E-mail: hesselb@psychiatry.uchc.edu.

Abstract

Abstract: Background: Suicide and suicidal behavior are prevalent among individuals with psychiatric disorders, including alcohol dependence. A genome screen was performed in multiplex alcohol dependent families ascertained as part of the Collaborative Study on the Genetics of Alcoholism to identify chromosomal regions of interest related to two types of suicidal behavior: suicide attempts and suicidality.

Methods: Sibling pair analyses were used to conduct linkage analyses using both qualitative and quantitative suicide-related phenotypes. The qualitative trait of “suicide attempts” was examined using 59 affected sibling pairs. The quantitative trait of “suicidality” was examined using all possible 1366 sibling pairs and 705 independent sibling pairs.

Results: For the qualitative phenotype suicide attempts, chromosome 2 yielded a maximum lod score of 4.2. For the quantitative suicidality index, a maximum lod score of 1.8 was observed on chromosome 3, and a lod score of 1.5 was found on chromosome 1.

Conclusions: This study represents the first genome-wide scan of suicidal behavior. Significant evidence of linkage was found on chromosome 2 for the phenotype suicide attempts, the same chromosomal region previously reported to be linked to alcohol dependence in this sample. This finding does not seem to be due solely to an association between suicide and alcohol dependence. There was more modest evidence of linkage to chromosomes 1 and 3 for suicidality; however, these findings did not reach statistical significance. There was no overlap in findings for these two phenotypes of suicidal behavior.

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