ADH1B*1, ADH1C*2, DRD2 (−141C Ins), and 5-HTTLPR Are Associated With Alcoholism in Mexican American Men Living in Los Angeles

Authors

  • Tamiko Konishi,

    1. Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA
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  • Huai-Rong Luo,

    1. Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.
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  • Maria Calvillo,

    1. Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA
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  • Matthew S. Mayo,

    1. Department of Preventive Medicine and Public Health and Kansas Masonic Cancer Research Institute, University of Kansas Medical Center, Kansas City, Kansas.
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  • Keh-Ming Lin,

    1. Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA
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  • Yu-Jui Yvonne Wan

    Corresponding author
    1. Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.
      Yu-Jui Yvonne Wan, PhD, Professor of Pharmacology, Toxicology & Therapeutics, Mail Stop 1018 Breidenthal Building, The University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7417; Fax: 913-588-7501; E-mail: ywan@kumc.edu.
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  • Supported by Grants RO1 AA12081 and RO1 AA12081–02S1 from NIAAA.

Yu-Jui Yvonne Wan, PhD, Professor of Pharmacology, Toxicology & Therapeutics, Mail Stop 1018 Breidenthal Building, The University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7417; Fax: 913-588-7501; E-mail: ywan@kumc.edu.

Abstract

Background: The aim of the present study was to use a candidate gene approach to identify the genetic risk factors for alcoholism in Mexican Americans residing in the Los Angeles area. The genes selected include alcohol metabolizing genes and neurotransmitter genes, which have been shown in the literature to be associated with alcoholism in other ethnic groups.

Methods: Thirteen allelic variants from seven genes were evaluated for their role in alcoholism using alcoholic (n= 200) and nonalcoholic (n= 251) Mexican Americans. Those polymorphic sites include alcohol dehydrogenase (ADH1B, ADH1C), aldehyde dehydrogenase (ALDH2), cytochrome P-450 2E1 (CYP2E1) TaqI, DraI, RsaI, dopamine D2 receptor (DRD2) TaqI A, B, intron 6, exon 7, −141C Ins/Del, serotonin transporter (5-HTTLPR), and GABAA receptor β3 subunit (GABRβ3).

Results: The results demonstrate that Mexican Americans have extremely low allele frequency for both ALDH2*2 and ADH1B*2 and a relatively high frequency of ADH1C*2 and CYP2E1 c2 alleles. ADH1B*1, ADH1C*2, DRD2 (−141C Ins), and 5-HTTLPR were associated with alcoholism in Mexican Americans (p < 0.05). DRD2 Ins was associated with alcoholism in those alcoholics who carried the ADH1B*2 or ADH1C*1 protective alleles (p= 0.032 in genotype level and p= 0.015 in allele level). DRD2 TaqI A and B alleles were associated with early age of onset for drinking (p= 0.016 for TaqI A1 and p= 0.049 for TaqI B1 allele).

Conclusions: Together, the data reveal unique genetic patterns in Mexican Americans that may be in part responsible for the heightened risk for alcoholism and alcohol-associated health problems in this population.

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