Multicenter Validation Study of the %CDT TIA Kit in Alcohol Abuse and Alcohol Dependence

  1. Raymund Schwan1,*,
  2. Marie-Nadia Loiseaux2,
  3. François Schellenberg3,
  4. Eliane Albuisson6,
  5. Jean-Dominique Favre4,
  6. Alain Rigaud5,
  7. Pierre-Michel Llorca1,
  8. Claudine Gillet7,
  9. Michel Reynaud8

Article first published online: 3 MAY 2006

DOI: 10.1097/01.ALC.0000139813.14716.CD

Issue

Alcoholism: Clinical and Experimental Research

Alcoholism: Clinical and Experimental Research

Volume 28, Issue 9, pages 1331–1337, September 2004

Additional Information

How to Cite

Schwan, R., Loiseaux, M.-N., Schellenberg, F., Albuisson, E., Favre, J.-D., Rigaud, A., Llorca, P.-M., Gillet, C. and Reynaud, M. (2004), Multicenter Validation Study of the %CDT TIA Kit in Alcohol Abuse and Alcohol Dependence. Alcoholism: Clinical and Experimental Research, 28: 1331–1337. doi: 10.1097/01.ALC.0000139813.14716.CD

Author Information

  1. 1

    Department of Psychiatry, University Hospital, Clermont-Ferrand, France

  2. 2

    Biochemistry Department, University Hospital, Clermont-Ferrand, France

  3. 3

    Biochemistry Department, University Hospital, Tours, France

  4. 4

    Department of Psychiatry, Clamart Military Hospital, Reims, France

  5. 5

    Department of Psychiatry, Alcohol Treatment Center, Reims, France

  6. 6

    Department of Internal Medicine and Biostatistics and Medical Information Technology, Nancy, France

  7. 7

    University Hospital Cente, Nancy, France

  8. 8

    Department of Psychiatry, University Medical School, Villejuif, France.

*Reprint requests: Raymund Schwan, MD, PhD, Centre Médico-Psychologique B, rue Montalembert, F-63003 Clermont-Ferrand, Cedex 1, France; Fax: 33-4-73-75-20-74; E-mail: rschwan@chu-clermontferrand.fr

Publication History

  1. Issue published online: 3 MAY 2006
  2. Article first published online: 3 MAY 2006
  3. Received for publication September 18, 2003; accepted May 12, 2004.

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Keywords:

  • Carbohydrate-Deficient Transferrin;
  • γ-Glutamyl Transferase;
  • Alcohol Abuse;
  • Alcohol Dependence;
  • %CDT TIA

Background: Carbohydrate-deficient transferrin (CDT) and γ-glutamyl transferase (GGT) are used as biomarkers of alcohol misuse. The aim of this study was to evaluate, in terms of sensitivity and specificity, the performance of the new Bio-Rad %CDT TIA kit and GGT assay for identifying alcohol abuse and alcohol dependence (according to the DSM-IV criteria).

Methods: An open multicenter study (30 centers) over 3 months, including patient groups of “abusers,”“dependents,” and controls, was conducted in France.

Results: In alcohol abuse, the sensitivity of GGT was 0.56, and that of CDT was 0.80; in alcohol dependence, the sensitivity of GGT was 0.86, and that of CDT was 0.91. The specificity of GGT was 0.77, and that of CDT was 0.83. The association of GGT with CDT increased sensitivity for alcohol abuse to 0.90 and for alcohol dependence to 0.99, but it appreciably decreased specificity (0.63).

Conclusions: %CDT is the better screening marker for alcohol abuse and dependence, but GGT is still a useful marker for the detection of alcohol dependence. As an assay method, the second-generation Bio-Rad %CDT immunoassay can be recommended for routine CDT measurement.

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