CDT Values Are Not Influenced by Epithelial Cell Apoptosis in Chronic Alcoholic Patients—Preliminary Results

Authors


Reprint requests: Katrin Ramskogler MD, University of Vienna, Department of Psychiatry, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Abstract

Carbohydrate-deficient transferrin (CDT) has been well established as a marker for high alcohol consumption. As studies concerning the specificity of CDT in patients with liver disease have shown controversial outcomes, efforts to illuminate mechanisms leading to impaired CDT specificity in this patient group cannot yet be considered successful. Evidence of apoptosis as examined in 72 alcohol-dependent patients using serum contents of caspase-related M30 monoclonal antibody significantly correlated with aspartate aminotransferase, alanine aminotransferase, and γ-glutamyl transpeptidase but did not influence CDT levels. These results suggest that impairment of CDT specificity is brought forth by derangement of hepatic metabolism rather than by acute hepatocellular damage.

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