CDT Values Are Not Influenced by Epithelial Cell Apoptosis in Chronic Alcoholic Patients—Preliminary Results

  1. Katrin Ramskogler1,*,
  2. Markus Brunner2,
  3. Ines Hertling1,
  4. Alexander Dvorak1,
  5. Nestor Kapusta1,
  6. Claus Krenn3,
  7. Bernhard Moser2,
  8. Georg Roth2,
  9. Otto Michael Lesch1,4,
  10. Hendrik Jan Ankersmit2,
  11. Henriette Walter1

Article first published online: 3 MAY 2006

DOI: 10.1097/01.ALC.0000139818.68555.8A

Issue

Alcoholism: Clinical and Experimental Research

Alcoholism: Clinical and Experimental Research

Volume 28, Issue 9, pages 1396–1398, September 2004

Additional Information

How to Cite

Ramskogler, K., Brunner, M., Hertling, I., Dvorak, A., Kapusta, N., Krenn, C., Moser, B., Roth, G., Lesch, O. M., Ankersmit, H. J. and Walter, H. (2004), CDT Values Are Not Influenced by Epithelial Cell Apoptosis in Chronic Alcoholic Patients—Preliminary Results. Alcoholism: Clinical and Experimental Research, 28: 1396–1398. doi: 10.1097/01.ALC.0000139818.68555.8A

Author Information

  1. 1

    Department of Psychiatry, Medical University of Vienna, Vienna, Austria

  2. 2

    Department of CT-Surgery, Medical University of Vienna, Vienna, Austria

  3. 3

    Department of Anaesthesiology, Medical University of Vienna, Vienna, Austria

  4. 4

    Anton Proksch Institute for Treatment of Alcoholism.

*Reprint requests: Katrin Ramskogler MD, University of Vienna, Department of Psychiatry, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Publication History

  1. Issue published online: 3 MAY 2006
  2. Article first published online: 3 MAY 2006
  3. Received for publication March 25, 2004; accepted May 5, 2004.

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Carbohydrate-deficient transferrin (CDT) has been well established as a marker for high alcohol consumption. As studies concerning the specificity of CDT in patients with liver disease have shown controversial outcomes, efforts to illuminate mechanisms leading to impaired CDT specificity in this patient group cannot yet be considered successful. Evidence of apoptosis as examined in 72 alcohol-dependent patients using serum contents of caspase-related M30 monoclonal antibody significantly correlated with aspartate aminotransferase, alanine aminotransferase, and γ-glutamyl transpeptidase but did not influence CDT levels. These results suggest that impairment of CDT specificity is brought forth by derangement of hepatic metabolism rather than by acute hepatocellular damage.

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