CDT Values Are Not Influenced by Epithelial Cell Apoptosis in Chronic Alcoholic Patients—Preliminary Results
Article first published online: 3 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 28, Issue 9, pages 1396–1398, September 2004
How to Cite
Ramskogler, K., Brunner, M., Hertling, I., Dvorak, A., Kapusta, N., Krenn, C., Moser, B., Roth, G., Lesch, O. M., Ankersmit, H. J. and Walter, H. (2004), CDT Values Are Not Influenced by Epithelial Cell Apoptosis in Chronic Alcoholic Patients—Preliminary Results. Alcoholism: Clinical and Experimental Research, 28: 1396–1398. doi: 10.1097/01.ALC.0000139818.68555.8A
- Issue published online: 3 MAY 2006
- Article first published online: 3 MAY 2006
- Received for publication March 25, 2004; accepted May 5, 2004.
Carbohydrate-deficient transferrin (CDT) has been well established as a marker for high alcohol consumption. As studies concerning the specificity of CDT in patients with liver disease have shown controversial outcomes, efforts to illuminate mechanisms leading to impaired CDT specificity in this patient group cannot yet be considered successful. Evidence of apoptosis as examined in 72 alcohol-dependent patients using serum contents of caspase-related M30 monoclonal antibody significantly correlated with aspartate aminotransferase, alanine aminotransferase, and γ-glutamyl transpeptidase but did not influence CDT levels. These results suggest that impairment of CDT specificity is brought forth by derangement of hepatic metabolism rather than by acute hepatocellular damage.