This work was supported by the Whitaker Foundation (RG-02–0126, EDM), by the NIAAA-sponsored Alcohol Research Center at Indiana University (P60 AA07611–17, DAK), and by the General Clinical Research Center at Indiana University Hospital.
Dopamine D2 Receptor Availability is Associated with Subjective Responses to Alcohol
Article first published online: 3 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 29, Issue 6, pages 965–970, June 2005
How to Cite
Yoder, K. K., Kareken, D. A., Seyoum, R. A., O’Connor, S. J., Wang, C., Zheng, Q.-H., Mock, B. and Morris, E. D. (2005), Dopamine D2 Receptor Availability is Associated with Subjective Responses to Alcohol. Alcoholism: Clinical and Experimental Research, 29: 965–970. doi: 10.1097/01.ALC.0000171041.32716.42
- Issue published online: 3 MAY 2006
- Article first published online: 3 MAY 2006
- Received for publication January 20, 2005; accepted March 30, 2005.
The mesolimbic dopaminergic system is thought to mediate alcohol abuse and dependence. Determining the relationship between in vivo dopamine and the subjective response to alcohol could improve understanding of the mechanisms that lead to alcohol abuse and dependence. Here, we examined the relationship between dopamine D2 receptors in the nucleus accumbens and scores of perceived “high” and “intoxication” during an intravenous (IV) alcohol infusion.
Nine healthy control subjects received 11Craclopride PET scanning at baseline. Eight subjects received a second 11Craclopride scan during a pharmacodynamically modeled and controlled rise of IV alcohol, followed by steady state (60 mg%± 5 mg%) alcohol infusion. Numerical ratings of “high” and “intoxication” were tested for correlations with measures of dopaminergic function.
Baseline D2 receptor availability in the left nucleus accumbens was significantly correlated with peak perceived “intoxication” (p= 0.02) and marginally correlated with peak perceived “high” (p= 0.07).
Resting D2 receptor availability may predict healthy subject responses to alcohol exposure.