Inflammatory bowel disease in patients with celiac disease
Article first published online: 14 DEC 2006
Copyright © 2005 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 11, Issue 6, pages 528–532, June 2005
How to Cite
Yang, A., Chen, Y., Scherl, E., Neugut, A. I., Bhagat, G. and Green, P. H. R. (2005), Inflammatory bowel disease in patients with celiac disease. Inflamm Bowel Dis, 11: 528–532. doi: 10.1097/01.MIB.0000161308.65951.db
- Issue published online: 14 DEC 2006
- Article first published online: 14 DEC 2006
- Manuscript Accepted: 23 FEB 2005
- Manuscript Received: 20 FEB 2005
- celiac disease;
- inflammatory bowel disease
Background: Several case reports and series report an association between celiac disease and inflammatory bowel disease (IBD); however, there is no current data assessing this association. We therefore studied the occurrence of these conditions in a cohort of patients with celiac disease seen at a referral center.
Methods: A database of patients with celiac disease seen between 1981 and 2002 was analyzed. Only biopsy-proven adults were included. Patients who had endoscopic and pathologic evidence of IBD were identified, and their pathology was reviewed. Age- and sex-adjusted prevalence rate ratios were determined by comparing results with population-based prevalence data.
Results: Among 455 patients with celiac disease, IBD was identified in 10 (5 had ulcerative colitis and 5 had Crohn's disease). This represented an age- and sex-adjusted prevalence rate ratio for ulcerative colitis of 3.56 (95% confidence interval, 1.48-8.56) and for Crohn's disease of 8.49 (95% confidence interval, 3.53-20.42).
Conclusion: Within our cohort of patients with celiac disease, IBD was significantly more common than in the general population.