This work was supported by grants from the National Institute on Deafness and Other Communication Disorders, DC00022(T32 Jacob, PI: Neely), DC04890 to 01A1(RO-3 PI: Jacob), a Core grant (P30 DC004665 PI: Simmons), and the Department of Otolaryngology.
Survey Anatomy of the Paranasal Sinuses in the Normal Mouse†
Article first published online: 2 JAN 2009
Copyright © 2006 The Triological Society
Volume 116, Issue 4, pages 558–563, April 2006
How to Cite
Jacob, A. and Chole, R. A. (2006), Survey Anatomy of the Paranasal Sinuses in the Normal Mouse. The Laryngoscope, 116: 558–563. doi: 10.1097/01.MLG.0000202085.23454.2F
Abraham Jacob, Department of Otolaryngology-Head and Neck Surgery, The Ohio State University School of Medicine, 456 W. 10th Avenue, Room 4024 B, Columbus, OH 43210, U.S.A.
- Issue published online: 2 JAN 2009
- Article first published online: 2 JAN 2009
- Manuscript Accepted: 20 DEC 2005
- sinonasal anatomy;
- normal mouse sinus anatomy
Objective: To provide researchers with a survey atlas of normal paranasal sinus anatomy in the mouse as well as to standardize the reporting of data within the murine nose and sinuses.
Study Design: Histologic and radiographic study in mice.
Methods: C57BL/6 mice were killed and their heads sectioned in the axial and coronal planes as well as imaged using a small animal micro-computed tomography (CT) scanner. Distinctive regions within the nose and paranasal sinuses were delineated and labeled A to G for identification.
Results: Definable regions within the normal murine nose and paranasal sinuses include A) the nasal airway, B) the superior nasal vault, C) the osteomeatal complex, D) the anterior ethmoid sinuses, E) the posterior ethmoid sinuses, F) the true maxillary sinus, and G) the secondary maxillary sinus. Mice also possess discernible sphenoid sinuses. CT scans confirmed the histologic plane of section.
Conclusions: A survey atlas of normal murine sinonasal anatomy shall provide laboratories seeking to use mice in sinus research a reference for beginning their work. As new transgenic and gene knockout mice become available, phenotypic changes in sinonasal architecture can be more easily discerned using such a reference. Defining specific regions (A-G) within the sinuses will standardize the nomenclature used for reporting data.