Supported by National Institute on Alcohol Abuse and Alcoholism grants 1R21AA12284-01, KO5AA00093, P50AA03527, RO1-AA12650, and 5 R21 AA12284-02 to R. A. Deitrich, University of Colorado Alcohol Research Center.
Is Ethanol a Pro-Drug? Acetaldehyde Contribution to Brain Ethanol Effects
Article first published online: 3 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 29, Issue 8, pages 1514–1521, August 2005
How to Cite
Quertemont, E., Eriksson, C. J. P., Zimatkin, S. M., Pronko, P. S., Diana, M., Pisano, M., Rodd, Z. A., Bell, R. R. and Ward, R. J. (2005), Is Ethanol a Pro-Drug? Acetaldehyde Contribution to Brain Ethanol Effects. Alcoholism: Clinical and Experimental Research, 29: 1514–1521. doi: 10.1097/01.alc.0000175015.51329.45
- Issue published online: 3 MAY 2006
- Article first published online: 3 MAY 2006
- Received for publication January 27, 2005; accepted March 10, 2005.
This article presents the proceedings of a symposium at the 2004 meeting of the International Society for Biomedical Research on Alcoholism, held in Mannheim, Germany. The symposium was organized by Etienne Quertemont and chaired by C. J. Peter Eriksson. The presentations were (1) Brain ethanol metabolism and its behavior consequences, by Sergey M. Zimatkin and P. S. Pronko; (2) Acetaldehyde increases dopaminergic neuronal activity: a possible mechanism for acetaldehyde reinforcing effects, by Marco Diana and Milena Pisano; (3) Contrasting the reinforcing actions of acetaldehyde and ethanol within the ventral tegmental area (VTA) of alcohol-preferring (P) rats, by Zachary A. Rodd and Richard R. Bell; (4) Molecular and biochemical changes associated with acetaldehyde toxicity, by Roberta J. Ward; and (5) Role of acetaldehyde in human alcoholism and alcohol abuse, by C. J. Peter Eriksson.