Adolescent Vulnerabilities to Chronic Alcohol or Nicotine Exposure: Findings From Rodent Models

Authors

  • Susan Barron,

    Corresponding author
    1. Psychology Department, University of Kentucky, Lexington, KY (SB); Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana (RLB, ZAR); the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina (AW, HSS, EDL, AHR); Scripps Research Institute, La Jolla, California (CJS, CLE); and the Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York (LPS).
      Reprint requests: Dr. Susan Barron, Kastle Hall, Lexington, KY, 40506-0044; Fax: 606-323-1979; E-mail: sbarron@uky.edu
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  • Aaron White,

    1. Psychology Department, University of Kentucky, Lexington, KY (SB); Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana (RLB, ZAR); the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina (AW, HSS, EDL, AHR); Scripps Research Institute, La Jolla, California (CJS, CLE); and the Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York (LPS).
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  • H Scott Swartzwelder,

    1. Psychology Department, University of Kentucky, Lexington, KY (SB); Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana (RLB, ZAR); the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina (AW, HSS, EDL, AHR); Scripps Research Institute, La Jolla, California (CJS, CLE); and the Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York (LPS).
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  • Richard L. Bell,

    1. Psychology Department, University of Kentucky, Lexington, KY (SB); Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana (RLB, ZAR); the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina (AW, HSS, EDL, AHR); Scripps Research Institute, La Jolla, California (CJS, CLE); and the Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York (LPS).
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  • Zachary A. Rodd,

    1. Psychology Department, University of Kentucky, Lexington, KY (SB); Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana (RLB, ZAR); the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina (AW, HSS, EDL, AHR); Scripps Research Institute, La Jolla, California (CJS, CLE); and the Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York (LPS).
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  • Craig J. Slawecki,

    1. Psychology Department, University of Kentucky, Lexington, KY (SB); Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana (RLB, ZAR); the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina (AW, HSS, EDL, AHR); Scripps Research Institute, La Jolla, California (CJS, CLE); and the Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York (LPS).
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  • Cindy L. Ehlers,

    1. Psychology Department, University of Kentucky, Lexington, KY (SB); Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana (RLB, ZAR); the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina (AW, HSS, EDL, AHR); Scripps Research Institute, La Jolla, California (CJS, CLE); and the Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York (LPS).
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  • Edward D. Levin,

    1. Psychology Department, University of Kentucky, Lexington, KY (SB); Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana (RLB, ZAR); the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina (AW, HSS, EDL, AHR); Scripps Research Institute, La Jolla, California (CJS, CLE); and the Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York (LPS).
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  • Amir H. Rezvani,

    1. Psychology Department, University of Kentucky, Lexington, KY (SB); Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana (RLB, ZAR); the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina (AW, HSS, EDL, AHR); Scripps Research Institute, La Jolla, California (CJS, CLE); and the Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York (LPS).
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  • Linda P. Spear

    1. Psychology Department, University of Kentucky, Lexington, KY (SB); Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana (RLB, ZAR); the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina (AW, HSS, EDL, AHR); Scripps Research Institute, La Jolla, California (CJS, CLE); and the Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York (LPS).
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  • Supported in part by grants AA12600 and AA14032 (to SB), AA10256 and AA11261 (to RLB), AA12478 and VA Senior Research Career Scientist Award (to HSS), AA00298 and AA014339 (to CJS), AA06059 (to CLE), DA015756 and MH64494 (to EDL), and AA12150 and AA12525 (to LPS).

Reprint requests: Dr. Susan Barron, Kastle Hall, Lexington, KY, 40506-0044; Fax: 606-323-1979; E-mail: sbarron@uky.edu

Abstract

This article presents an overview of the proceedings from a symposium entitled “Is adolescence special? Possible age-related vulnerabilities to chronic alcohol or nicotine exposure,” organized by Susan Barron and Linda Spear and held at the 2004 Research Society on Alcoholism Meeting in Vancouver, British Columbia. This symposium, cosponsored by the Fetal Alcohol Syndrome Study Group and the Neurobehavioral Teratology Society, focused on our current knowledge regarding the long-term consequences of ethanol and/or nicotine exposure during adolescence with the emphasis on data from rodent models. The support from these two societies represents the understanding by these research groups that adolescence represents a unique developmental stage for the effects of chronic drug exposure and also marks an age in which many risky behaviors including alcohol consumption and smoking typically begin. The speakers included (1) Aaron White, who presented data on the effects of adolescent ethanol exposure on subsequent motor or cognitive response to an ethanol challenge in adulthood; (2) Richard Bell, who presented data suggesting that genetic differences could play a role in adolescent vulnerability to ethanol; (3) Craig Slawecki, who presented data looking at the effects of chronic exposure to alcohol or nicotine on neurophysiologic and behavioral end points; and (4) Ed Levin, who presented data on acute and long-term consequences of adolescent nicotine exposure. Finally, Linda Spear provided some summary points and recommendations regarding unresolved issues and future directions.

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