Protective Effects of Glucocorticoids on Ischemia–Reperfusion Injury of Outer Hair Cells
Article first published online: 2 JAN 2009
Copyright © 2006 The Triological Society
Volume 116, Issue 4, pages 627–629, April 2006
How to Cite
Tabuchi, K., Oikawa, K., Murashita, H., Hoshino, T., Tsuji, S. and Hara, A. (2006), Protective Effects of Glucocorticoids on Ischemia–Reperfusion Injury of Outer Hair Cells. The Laryngoscope, 116: 627–629. doi: 10.1097/01.mlg.0000200963.69342.d7
- Issue published online: 2 JAN 2009
- Article first published online: 2 JAN 2009
- Manuscript Accepted: 7 DEC 2005
- outer hair cells
Objective: This animal study aimed to investigate effects of glucocorticoids on the functional recovery of outer hair cells (OHCs) after transient ischemia.
Methods: Distortion-product otoacoustic emission (DPOAE) was examined before, during, and after transient cochlear ischemia of 30 minutes using albino guinea pigs.
Results: DPOAE decreased to noise level during ischemia. On recirculation, DPOAE initially recovered with time until 20 minutes after the onset of reperfusion, but thereafter, the DPOAE level gradually decreased toward the noise level in the control animals. Prednisolone and methylprednisolone significantly improved the DPOAE level 60 minutes after the onset of reperfusion.
Conclusions: The present findings suggest that glucocorticoids possess protective effects against ischemia–reperfusion injury of OHCs.