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Protective Effects of Glucocorticoids on Ischemia–Reperfusion Injury of Outer Hair Cells

Authors

  • Keiji Tabuchi MD,

    Corresponding author
    1. Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    • Dr. Keiji Tabuchi, Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan
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  • Keiko Oikawa MD,

    1. Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
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  • Hidekazu Murashita MD,

    1. Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
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  • Tomofumi Hoshino MD,

    1. Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
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  • Shigeki Tsuji MD,

    1. Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
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  • Akira Hara MD

    1. Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
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Abstract

Objective: This animal study aimed to investigate effects of glucocorticoids on the functional recovery of outer hair cells (OHCs) after transient ischemia.

Methods: Distortion-product otoacoustic emission (DPOAE) was examined before, during, and after transient cochlear ischemia of 30 minutes using albino guinea pigs.

Results: DPOAE decreased to noise level during ischemia. On recirculation, DPOAE initially recovered with time until 20 minutes after the onset of reperfusion, but thereafter, the DPOAE level gradually decreased toward the noise level in the control animals. Prednisolone and methylprednisolone significantly improved the DPOAE level 60 minutes after the onset of reperfusion.

Conclusions: The present findings suggest that glucocorticoids possess protective effects against ischemia–reperfusion injury of OHCs.

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