Water May Cure Patients With Meniere Disease

Authors

  • Hideaki Naganuma MD,

    Corresponding author
    1. Department of Otorhinolaryngology, Kitasato University School of Medicine, Kitasato Sagamihara Kanagawa, Japan.
    • Hideaki Naganuma, MD, Assistant Professor, Department of Otorhinolaryngology, Kitasato University School of Medicine, 1-15-1 Kitasato Sagamihara Kanagawa, Japan, 228-8555.
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  • Katsumasa Kawahara MD,

    1. Department of Physiology, Kitasato University School of Medicine, Kitasato Sagamihara Kanagawa, Japan.
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  • Koji Tokumasu MD,

    1. Department of Otorhinolaryngology, Kitasato University School of Medicine, Kitasato Sagamihara Kanagawa, Japan.
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  • Makito Okamoto MD

    1. Department of Otorhinolaryngology, Kitasato University School of Medicine, Kitasato Sagamihara Kanagawa, Japan.
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  • Parts of this paper were presented at the 63rd Annual Meeting of Japan Society for Equilibrium Research, Takasaki, Japan, November 17–19, 2004; the 106th Annual Meeting of the Oto-Rhino-Laryngological Society of Japan, Osaka, Japan, May 19–21, 2005; and the 64th Annual Meeting of Japan Society for Equilibrium Research, Tokyo, Japan, November 24–25, 2005.

    This work was supported in part by Grant-in-Aid for Research (C) No. 13671797 and No. 15591829 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan and a grant from the Graduate School of Medical Science, Kitasato University.

Abstract

Objectives/Hypothesis: We examined whether sufficient water intake is effective in the long-term control of vertigo and hearing activity in patients with Meniere disease (MD) for whom conventional therapy has proven unsuccessful.

Study Design: The authors conducted a time-series study with historical control.

Methods: Eighteen patients with MD in group 1 drank 35 mL/kg per day of water for 2 years. Twenty-nine patients with MD treated with the conventional dietary and diuretic therapy for more than 2 years during 1992 to 1999 at the same hospital were enrolled in a historical control of group 2.

Results: Patients in group 1 dramatically relieved vertigo and significantly improved in the hearing of the worst pure-tone average of three frequencies (0.125, 0.25, and 0.5 kHz) (low PTA) during the last 6 months of the study period. In contrast, patients in group 2 became worse in both the four- (0.5, 1, 2, and 4 kHz) frequency PTA and the low PTA, although their vertigo did improve. The number of patients whose hearing were improved, unchanged, and worse were 4, 12, and 2 in group 1 and 2, 11, and 16 in group 2, respectively.

Conclusion: Deliberate modulation of the intake of water may be the simplest and most cost-effective medical treatment for patients with MD. Larger studies will be needed to confirm these results in a larger patient cohort.

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