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A Paranasal Tumor Associated With Tumor-Induced Osteomalacia

Authors

  • Go Inokuchi MD,

    1. Department of Otorhinolaryngology–Head and Neck Surgery (g.i., h.t., h.i., k.-i.n.), Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
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  • Hitoshi Tanimoto MD,

    Corresponding author
    1. Department of Otorhinolaryngology–Head and Neck Surgery (g.i., h.t., h.i., k.-i.n.), Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    • Hitoshi Tanimoto, MD, Department of Otorhinolaryngology–Head and Neck Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
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  • Haruhiko Ishida MD,

    1. Department of Otorhinolaryngology–Head and Neck Surgery (g.i., h.t., h.i., k.-i.n.), Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
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  • Toshitsugu Sugimoto MD,

    1. Department of Endocrinology, Metabolism, and Hematological Oncology, Shimane University School of Medicine, Izumo, Shimane, Japan
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  • Mika Yamauchi MD,

    1. Department of Endocrinology, Metabolism, and Hematological Oncology, Shimane University School of Medicine, Izumo, Shimane, Japan
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  • Akimitsu Miyauchi MD,

    1. Department of Medicine, National Hyogo-Chuo Hospital, Hyogo, Japan.
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  • Ken-ichi Nibu MD

    1. Department of Otorhinolaryngology–Head and Neck Surgery (g.i., h.t., h.i., k.-i.n.), Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
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Abstract

Background: Tumor-induced osteomalacia (TIO) is an extremely rare paraneoplastic syndrome associated with mesenchymal tumors in the craniofacial region.

Methods: We treated a 24-year-old Japanese woman with paranasal sinus tumor and a low serum phosphate level who presented with nasal obstruction and systemic bone fractures. Serum fibroblast growth factor 23 (FGF-23) was measured before and after surgery.

Results: After surgery, her symptoms were resolved and the serum phosphate and FGF-23 levels became normalized.

Conclusion: FGF-23 is thought to be a useful diagnostic marker in patients with craniofacial tumors associated with multiple systemic fractures.

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