This work was supported by a grant for scientific research from the Ministry of Health, Spain (Instituto de Salud Carlosiii, PI020137).
Expression of Matrix Metalloproteinase-9 in High-Grade Salivary Gland Carcinomas is Associated With Their Metastatic Potential†
Article first published online: 2 JAN 2009
Copyright © 2008 The Triological Society
Volume 118, Issue 2, pages 247–251, February 2008
How to Cite
de Vicente, J. C., Lequerica-Fernández, P., López-Arranz, J. S., Esteban, I., Fresno, M. F. and Astudillo, A. (2008), Expression of Matrix Metalloproteinase-9 in High-Grade Salivary Gland Carcinomas is Associated With Their Metastatic Potential. The Laryngoscope, 118: 247–251. doi: 10.1097/MLG.0b013e318158f754
- Issue published online: 2 JAN 2009
- Article first published online: 2 JAN 2009
- Manuscript Accepted: 21 AUG 2007
- Salivary gland cancer;
- matrix metalloproteinase-9;
Objective: The aim of this study was to investigate the role of matrix metalloproteinase (MMP)-9 protein in high-grade malignant tumors of salivary gland origin as well as its utility as a prognostic marker.
Methods: Four micrometer sections from 27 malignant salivary neoplasms were immunostained using a specific antibody against MMP-9. The staining results (proportion of the stained tumor cells and intensity of tumor stainings) were correlated with the clinical data and with patient outcomes.
Results: Immunostaining for MMP-9 was observed in 17 cases, predominantly localized in the tumor cells and occasionally in the inflammatory stroma cells. MMP-9 protein expression correlated with N (P = .04), M (P = .02), and TNM stages (P = .03). MMP-9 expression was prognostic for shortened survival (P = .01). Our results show that the invasiveness and prognosis of high-grade salivary gland cancers may depend on their MMP-9 expression profile.