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Expression of Matrix Metalloproteinase-9 in High-Grade Salivary Gland Carcinomas is Associated With Their Metastatic Potential

Authors

  • Juan C. de Vicente MD, PhD,

    1. Instituto Universitario de Oncología del Principado de Asturias (IUOPA), del Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
    2. Servicio de Cirugía Maxilofacial, del Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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  • Paloma Lequerica-Fernández PhD,

    1. Instituto Universitario de Oncología del Principado de Asturias (IUOPA), del Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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  • Juan Sebastián López-Arranz MD, PhD,

    Corresponding author
    1. Instituto Universitario de Oncología del Principado de Asturias (IUOPA), del Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
    2. Servicio de Cirugía Maxilofacial, del Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
    • Dr. Juan Carlos de Vicente, Facultad de Medicina y Odontología (IUOPA), C/ Catedrático José Serrano s/n, 33006 Oviedo, Asturias, Spain.
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  • Isabel Esteban MD, PhD,

    1. Instituto Universitario de Oncología del Principado de Asturias (IUOPA), del Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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  • Manuel Florentino Fresno MD, PhD,

    1. Instituto Universitario de Oncología del Principado de Asturias (IUOPA), del Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
    2. Servicio de Patología, del Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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  • Aurora Astudillo MD, PhD

    1. Instituto Universitario de Oncología del Principado de Asturias (IUOPA), del Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
    2. Servicio de Patología, del Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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  • This work was supported by a grant for scientific research from the Ministry of Health, Spain (Instituto de Salud Carlosiii, PI020137).

Abstract

Objective: The aim of this study was to investigate the role of matrix metalloproteinase (MMP)-9 protein in high-grade malignant tumors of salivary gland origin as well as its utility as a prognostic marker.

Methods: Four micrometer sections from 27 malignant salivary neoplasms were immunostained using a specific antibody against MMP-9. The staining results (proportion of the stained tumor cells and intensity of tumor stainings) were correlated with the clinical data and with patient outcomes.

Results: Immunostaining for MMP-9 was observed in 17 cases, predominantly localized in the tumor cells and occasionally in the inflammatory stroma cells. MMP-9 protein expression correlated with N (P = .04), M (P = .02), and TNM stages (P = .03). MMP-9 expression was prognostic for shortened survival (P = .01). Our results show that the invasiveness and prognosis of high-grade salivary gland cancers may depend on their MMP-9 expression profile.

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