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Helicobacter pylori Colonization in the Larynges of Patients With Hoarseness

Authors

  • Tuan-Jen Fang MD,

    1. From the Department of Otolaryngology (t.-j.f.), Chang Gung Memorial Hospital, Keelung, Taiwan
    2. School of Medicine (t.-j.f., l.-a.l., h.-y.l., c.y.), College of Medicine, Chang Gung University, Taoyuan, Taiwan
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  • Li-Ang Lee MD,

    1. School of Medicine (t.-j.f., l.-a.l., h.-y.l., c.y.), College of Medicine, Chang Gung University, Taoyuan, Taiwan
    2. Departments of Otolaryngology (l.-a.l., h.-y.l.), Chang Gung Memorial Hospital, Taoyuan, Taiwan
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  • Hsueh-Yu Li MD,

    1. School of Medicine (t.-j.f., l.-a.l., h.-y.l., c.y.), College of Medicine, Chang Gung University, Taoyuan, Taiwan
    2. Departments of Otolaryngology (l.-a.l., h.-y.l.), Chang Gung Memorial Hospital, Taoyuan, Taiwan
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  • Chun Yang MD,

    1. School of Medicine (t.-j.f., l.-a.l., h.-y.l., c.y.), College of Medicine, Chang Gung University, Taoyuan, Taiwan
    2. Enterology (c.y.), Chang Gung Memorial Hospital, Taoyuan, Taiwan
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  • Chung-Guei Huang MSc

    Corresponding author
    1. Clinical Pathology (c.-g.h.), Chang Gung Memorial Hospital, Taoyuan, Taiwan
    2. School of Medical Biotechnology and Laboratory Science (c.-g.h.), Chang Gung University, Taoyuan, Taiwan.
    • Chung-Guei Huang, Department of Clinical Pathology, Chang Gung Memorial Hospital, 5, Fu-Shin street, Kueishan, 333, Taoyuan, Taiwan
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  • This study was partially presented at the 18th IFOS, Rome, Italy, June 2005, and at the annual meeting of AAO-HNS, Los Angles, California, U.S.A., September 2005.

  • The Chang Gung Memorial Hospital, Keelung, Taiwan supported this research under CMRPG240231.

Abstract

Objectives: Vocal nodules and polyps are two common noninfectious causes of hoarseness. Patients with persistent hoarseness often require microscopic laryngeal surgery to excise mass lesions of the larynx despite extensive voice resting and modification of voice use behavior. Helicobacter pylorihas recently been reported to present in the upper aerodigestive tract. This study applies the rapid urease test to determine the colonization of Helicobacter pylori in surgical specimens of patients with vocal nodules and polyps.

Methods: In this prospective study, 53 consecutive patients with vocal nodules (n = 20) or vocal polyps (n = 33) were investigated from November 2004 to July 2005. Microscopic laryngeal surgery was performed in all cases. Tissue specimens harvested from the larynx were analyzed using the rapid urease test.

Results: The study population consisted of 33 females and 20 males with a mean age of 43.1 ± 9.9 years. Thirteen (24.5%) of the 53 patients revealed Helicobacter pylori colonization, and all were histopathologically diagnosed with vocal polyps. The difference in incidence of Helicobacter pylori colonization between vocal nodules and vocal polyps was statistically significant (0% [0/20] vs. 39.4% [13/33], P = .001).

Conclusions:Helicobacter pylori often colonizes in the larynxes of patients with vocal polyps. These results indicate the involvement of Helicobacter pylori in vocal polyps. However, the presence of Helicobacter pylori as an etiologic factor in vocal polyps remains inconclusive.

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