Lecture American Laryngological Association, Jr. Lecture
Paradigms and Progress in Vocal Fold Restoration†
Article first published online: 2 JAN 2009
Copyright © 2008 The Triological Society
Volume 118, Issue 9, pages 1709–1713, September 2008
How to Cite
Ford, C. N. and Baker, D. C. (2008), Paradigms and Progress in Vocal Fold Restoration. The Laryngoscope, 118: 1709–1713. doi: 10.1097/MLG.0b013e31817c03c3
Presented at the American Laryngological Association and Triological Society Meeting during the Combined Otolaryngology Spring Meeting, Orlando, Florida, U.S.A. Editor's Note: This Manuscript was accepted for publication April 14, 2008.
- Issue published online: 2 JAN 2009
- Article first published online: 2 JAN 2009
- Vocal fold regeneration;
- tissue engineering;
- scientific progress;
Science advances occur through orderly steps, puzzle-solving leaps, or divergences from the accepted disciplinary matrix that occasionally result in a revolutionary paradigm shift. Key advances must overcome bias, criticism, and rejection. Examples in biological science include use of embryonic stem cells, recognition of Helicobacter pylori in the etiology of ulcer disease, and the evolution of species. Our work in vocal fold restoration reflects these patterns. We progressed through phases of tissue replacement with fillers and biological implants, to current efforts at vocal fold regeneration through tissue engineering, and face challenges of a new “systems biology” paradigm embracing genomics and proteomics.