The Role of Allergy and Smoking in Chronic Rhinosinusitis and Polyposis


  • Steven M. Houser MD, FACS,

    Corresponding author
    1. From the Department of Otolaryngology, Case Western Reserve University College of Medicine, Cleveland, Ohio, U.S.A.
    • Send correspondence to Steven M. Houser, MD, FACS, MetroHealth Medical Center, 2500 MetroHealth Dr., Cleveland OH 44109
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  • Kevin J. Keen PhD, PStat

    1. Mathematics University of Northern British Columbia, Prince George, British Columbia, Canada
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  • Editor's Note: This Manuscript was accepted for publication April 18, 2008.


Objectives/Hypothesis: The article considers the interrelatedness of allergic rhinitis and chronic rhinosinusitis (CRS). The negative impact of perennial allergy and tobacco use on polyposis in sinus surgery patients is explored.

Study Design: A retrospective chart review, performed by the first author over a 6-year period, of patients who underwent functional endoscopic sinus surgery for CRS.

Methods: The subjects' allergy status and smoking history are scrutinized by summary statistics and a multiple linear logistic model for predicting the presence of polyps.

Results: High prevalence of perennial allergic rhinitis (PAR) is seen in the subject population (56.4%). Both PAR and tobacco use are associated with nasal polyposis (P = .0073 and P = .0114, respectively).

Conclusions: The close association of PAR and CRS suggests a possible causal link. Management of allergic rhinitis and tobacco cessation may provide greater control of chronic hyperplastic rhinosinusitis.