Get access

A Genomewide Screen for Chronic Rhinosinusitis Genes Identifies a Locus on Chromosome 7q

Authors


  • *Currently at Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine Northwestern University, Chicago, Illinois, U.S.A.

    Supported by NIH grants from The University of Chicago General Clinical Research Center, T32 DC 00058-04 (to J.M.P.), T32 HL 007605 (to M.G.H.), HL56399 (to C.O.), HL66533 (to C.O.), M01 RR00055; and from the Mammalian Genotyping Service, HV-48141. Also supported by an American Geriatrics Society/Dennis W. Jahnigen Scholars Award (to J.M.P.).

Abstract

Objective/Hypothesis: Chronic rhinosinusitis (CRS) is an important public health problem with substantial impact on patient quality of life and health care costs. We hypothesized that genetic variation may be one factor that affects this disease.

Study Design: Identification of genetic variation underlying susceptibility to CRS using linkage analysis in a founder population.

Methods: We studied a religious isolate that practices a communal lifestyle and shares common environmental exposures. Using physical examination, medical interviews, and a review of medical records, we identified eight individuals with CRS of 291 screened. These eight individuals were related to each other in a single 60 member, nine generation pedigree. A genome-wide screen for loci influencing susceptibility to CRS using 1123 genome-wide markers was conducted.

Results: The largest linkage peak (P = .0023; 127.15 cM, equivalent to limit of detection = 2.01) was on chromosome 7q31.1–7q32.1, 7q31 (127.15 cM; 1-limit of detection support region: 115–135 cM) and included the CFTR locus. Genotyping of 38 mutations in the CFTR gene did not reveal variation accounting for this linkage signal.

Conclusions: Understanding the genes involved in CRS may lead to improvements in its diagnosis and treatment. Our results represent the first genome-wide screen for CRS and suggest that a locus on 7q31.1–7q32.1 influences disease susceptibility. This may be the CFTR gene or another nearby locus.

Ancillary