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Self-Ratings of Olfactory Function Reflect Odor Annoyance Rather than Olfactory Acuity

Authors


  • The Academy of Finland (grants 206327 [h.t., k.k., a.k.] and 108297 [k.s.]) and the European Commission (GenomEUtwin project under the “Quality of Life and Management of the Living Resources” of 5th Framework Programme [QLG2-CT-2002-01254]) and the Academy of Finland Centre of Excellence in Complex Disease Genetics (to j.k., k.s., and m.p.) are acknowledged for funding. Data collection of Finnish twins was supported by the National Institutes of Health grants AA-12502 (to rj rose), and by the Academy of Finland grant 205585 (j.k.).

Abstract

Objective/Hypothesis: Self-ratings of olfactory function often correlates poorly with results of objective smell tests. We explored these ratings relative to self-rating of odor annoyance, to odor identification ability, and to mean perceived intensity of odors, and estimated relative genetic and environmental contributions to these traits.

Participants and Methods: A total of 1,311 individual twins from the general population (62% females and 38% males, aged 10–83 years, mean age 29 years) including 191 monozygous and 343 dizygous complete twin pairs from Australia, Denmark, Finland, and the United Kingdom rated their sense of smell and annoyance caused by ambient smells (e.g., smells of foods) using seven categories, and performed odor identification and evaluation task for six scratch-and-sniff odor stimuli.

Results: The self-rating of olfactory function correlated with the self-rating of odor annoyance (r = 0.30) but neither correlated with the odor identification score. Quantitative genetic modeling revealed no unambiguously significant genetic contribution to variation in any of the studied traits.

Conclusion: The results suggest that environmental rather than genetic factors modify the self-rating of olfactory function and support earlier findings of discrepancy between subjective and objective measures of olfactory function. In addition, the results imply that the self-rating of olfactory function arises from experienced odor annoyance rather than from actual olfactory acuity.

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