Presented at ALA annual meeting in Orlando, 2008.
Regeneration of Aged Vocal Fold: First Human Case Treated With Fibroblast Growth Factor†
Article first published online: 2 JAN 2009
Copyright © 2008 The Triological Society
Volume 118, Issue 12, pages 2254–2259, December 2008
How to Cite
Hirano, S., Kishimoto, Y., Suehiro, A., Kanemaru, S.-i. and Ito, J. (2008), Regeneration of Aged Vocal Fold: First Human Case Treated With Fibroblast Growth Factor. The Laryngoscope, 118: 2254–2259. doi: 10.1097/MLG.0b013e3181845720
- Issue published online: 2 JAN 2009
- Article first published online: 2 JAN 2009
- Manuscript Accepted: 23 JUN 2008
- Aged vocal fold;
- basic fibroblast growth factor;
Background/Objectives: Aged vocal folds are characterized by atrophy of the mucosa, which causes dysphonia and is difficult to treat. We have revealed a therapeutic potential of basic fibroblast growth factor (bFGF) for tissue regeneration of the aged vocal fold. We report here the first human case that has been treated with bFGF.
Study Design: Institutional review board approved clinical human trial.
Methods: A 63-year-old man with atrophied vocal folds was treated by local injection of 10 μg of bFGF into the left vocal fold under topical anesthesia. The effects of the injection were examined after 1 to 3 months by videostroboscopy, acoustic and aerodynamic measurements.
Results: The atrophy of the vocal fold was improved at 1 week after the injection and glottic gap disappeared. Aerodynamic and acoustic parameters also showed remarkable improvement. These positive effects were maintained up to 3 months.
Conclusion: The first case with aged vocal folds treated with bFGF administration is presented. The results are encouraging, suggesting therapeutic effects of bFGF for atrophied vocal folds in human.