Chapter 1.3 Macromolecular crystallography and medicine

Crystallography of biological macromolecules

First Online Edition (2006)

Part 1. Introduction

  1. W. G. J. Hol,
  2. C. L. M. J. Verlinde

Published Online: 1 JAN 2006

DOI: 10.1107/97809553602060000656

International Tables for Crystallography

International Tables for Crystallography

How to Cite

Hol, W. G. J. and Verlinde, C. L. M. J. 2006. Macromolecular crystallography and medicine. International Tables for Crystallography. F:1:1.3:10–25.

Author Information

  1. Biomolecular Structure Center, Department of Biological Structure, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195-7742, USA

Publication History

  1. Published Online: 1 JAN 2006


Macromolecular crystallography is discussed in terms of its impact on medicine, and selected examples of protein structures of medical relevance are provided. The application of crystallography to the study of genetic diseases is covered, as well as the role of crystallography in the development of novel pharmaceuticals.


  • bacterial diseases;
  • blindness;
  • cancers;
  • cardiovascular disorders;
  • diabetes;
  • drug design;
  • drug metabolism;
  • drug resistance;
  • fungi;
  • genetic diseases;
  • helminths;
  • infectious diseases;
  • medicine and crystallography;
  • neurological disorders;
  • protozoan infections;
  • structure-based drug design;
  • vaccines;
  • viruses