Chapter 16.2 The maximum-entropy method

Crystallography of biological macromolecules

First Online Edition (2006)

Part 16. Direct methods

  1. G. Bricogne

Published Online: 1 JAN 2006

DOI: 10.1107/97809553602060000690

International Tables for Crystallography

International Tables for Crystallography

How to Cite

Bricogne, G. 2006. The maximum-entropy method. International Tables for Crystallography. F:16:16.2:346–351.

Author Information

  1. Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 2QH, England

Publication History

  1. Published Online: 1 JAN 2006


The maximum-entropy principle is discussed in a general context, and its adaptation to crystallography is described. There is an intimate connection between the maximum-entropy method and an enhancement of the probabilistic techniques of conventional direct methods known as the ‘saddlepoint method’.


  • direct methods;
  • Jaynes’ maximum-entropy principle;
  • maximum entropy;
  • random-atom model;
  • recentring;
  • saddlepoint method;
  • source entropy