Chapter 4.2 Crystallization of membrane proteins

Crystallography of biological macromolecules

Second Online Edition (2012)

Part 4. Crystallization

  1. H. Michel

Published Online: 14 APR 2012

DOI: 10.1107/97809553602060000813

International Tables for Crystallography

International Tables for Crystallography

How to Cite

Michel, H. 2012. Crystallization of membrane proteins. International Tables for Crystallography. F:4:4.2:122–128.

Author Information

  1. Max-Planck-Institut für Biophysik, Heinrich-Hoffmann-Strasse 7, D-60528 Frankfurt/Main, Germany

Publication History

  1. Published Online: 14 APR 2012


The crystallization of membrane proteins is described. The topics covered include the principles of membrane-protein crystallization, general properties of detergents relevant to membrane-protein crystallization, the ‘small amphiphile concept’, membrane-protein crystallization with the help of antibody Fv fragments and membrane-protein crystallization using cubic bicontinuous lipidic phases. General recommendations on crystallizing membrane proteins are provided, and membrane proteins with known structures and potentially useful detergents are tabulated.


  • antibody Fv fragments in crystallization of membrane proteins;
  • crystallization;
  • cubic bicontinuous lipidic phases;
  • detergents;
  • membrane proteins;
  • small amphiphile concept