Chapter 17.1 Macromolecular model building and validation using Coot
Crystallography of biological macromolecules
Second Online Edition (2012)
Part 17. Model building and computer graphics
Published Online: 14 APR 2012
© International Union of Crystallography 2006
International Tables for Crystallography
How to Cite
Emsley, P., Lohkamp, B. and Cowtan, K. 2012. Macromolecular model building and validation using Coot. International Tables for Crystallography. F:17:17.1:443–447.
- Published Online: 14 APR 2012
The Coot software package is a tool for interactive macromolecular model building and validation. The software is designed to be easy to learn for novice users by ensuring that tools for common tasks are ‘discoverable’ without consulting the documentation, while also providing enhanced usability for experts through customizable key bindings and extensive scripting interfaces. These considerations have resulted in substantial use throughout the crystallographic community. Coot displays electron-density maps and atomic models, and allows model manipulations such as idealization, real-space refinement, manual rotation/translation, rigid-body fitting, ligand search, solvation, mutations, rotamers and Ramachandran idealization. Several of the most important tools are described together with the underlying methods employed.
- model building;