Automated matching of high- and low-resolution structural models
Journal of Applied Crystallography
Volume 34, Issue 1, pages 33–41, February 2001
How to Cite
Kozin, M. B. and Svergun, D. I. (2001), Automated matching of high- and low-resolution structural models. Jnl Applied Crystallography, 34: 33–41. doi: 10.1107/S0021889800014126
A method is presented for automated best-matching alignment of three-dimensional models represented by ensembles of points. A normalized spatial discrepancy (NSD) is introduced as a proximity measure between three-dimensional objects. Starting from an inertia-axes alignment, the algorithm minimizes the NSD; the final value of the NSD provides a quantitative estimate of similarity between the objects. The method is implemented in a computer program. Simulations have been performed to test its performance on model structures with specified numbers of points ranging from a few to a few thousand. The method can be used for comparative analysis of structural models obtained by different methods, e.g. of high-resolution crystallographic atomic structures and low-resolution models from solution scattering or electron microscopy.