Crystallization and preliminary crystallographic data for the augmenter of liver regeneration
Acta Crystallographica Section D
Volume 53, Issue 3, pages 331–334, May 1997
How to Cite
Rose, J. P., Wu, C.-K., Francavilla, A., Prelich, J. G., Iacobellis, A., Hagiya, M., Rao, A. S., Starzl, T. E. and Wang, B.-C. (1997), Crystallization and preliminary crystallographic data for the augmenter of liver regeneration. Acta Crystallographica Section D, 53: 331–334. doi: 10.1107/S0907444996014084
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A new cellular growth factor termed augmenter of liver regeneration (ALR) has been crystallized. ALR has been shown to have a proliferative effect on liver cells while at the same time producing an immunosuppressive effect on liver-resident natural killer cells and liver-resident mononuclear leukocytes. In addition, ALR appears to play an important role in the synthesis and stabilization of mitochondrial gene transcripts in actively regenerating cells. ALR crystals diffract to beyond 2 Å resolution and belong to space group P21212, with a = 125.1, b = 108.1 and c = 38.5 Å. Based on four molecules per asymmetric unit, the Matthews coefficient is calculated to be 2.16 Å3 Da−1 which corresponds to a solvent content of 43%.