Validation of protein crystal structures
Acta Crystallographica Section D
Volume 56, Issue 3, pages 249–265, March 2000
How to Cite
Kleywegt, G. J. (2000), Validation of protein crystal structures. Acta Crystallographica Section D, 56: 249–265. doi: 10.1107/S0907444999016364
- quality criteria;
- quality-control methods.
Since the process of building and refining a model of a biomacromolecule based on crystallographic data is subjective, quality-control techniques are required to assess the validity of such models. During the 1990s, much experience was gained; the methods used and some of the lessons learned are reviewed here. In addition, an extensive compendium of quality criteria and quality-control methods that are or have been used to validate models of biomacromolecules has been compiled. The emphasis in this compendium is on the validation of protein crystal structures.