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Keywords:

  • circular dichroism spectroscopy;
  • protein secondary structures;
  • membrane proteins;
  • structural genomics.

This paper reviews the use of synchrotron radiation circular dichroism (SRCD) spectroscopy for examining protein structures, discussing the differences between conventional circular dichroism and SRCD, as well as examples of what SRCD studies have revealed about protein structures to date. It further discusses the future potential of the technique, including roles in structural genomics, membrane protein structure elucidation, relationships to crystallographic studies, and protein folding and dynamics.