Risperidone chloride 2.5-hydrate: a new crystalline form
DOI: 10.1107/S1600536806002157
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How to Cite
Wang, D.-H. and Pan, Y.-J. (2006), Risperidone chloride 2.5-hydrate: a new crystalline form. Acta Crystallographica Section E, 62: o768–o770. doi: 10.1107/S1600536806002157
The asymmetric unit of the title compound, C23H28FN4O2+·Cl−·2.5H2O, contain one risperidone cation {systematic name: 4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-[2-(2-methyl-4-oxo-3,4,6,7,8,9-hexahydro-2H-pyrido[1,2-a]pyrimidin-3-yl)ethyl]piperidinium}, one Cl− anion, and two and a half water molecules. The piperidine ring adopts a chair conformation, while the tetrahydropyridine ring has a sofa conformation. Each Cl− anion and the water molecules are linked to the risperidone molecules via O—H⋯O, O—H⋯N, O—H⋯Cl and N—H⋯Cl hydrogen bonds which stabilize the crystal packing.

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