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Eplerenone is an aldosterone receptor antagonist. Single crystals of the title compound [systematic name: 9α,11-epoxy-7α-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone dioxane solvate], C24H30O6·C4H8O2, were obtained from a dioxane solution. Within the eplerenone molecule, both five-membered rings display an envelope conformation. The three six-membered rings exhibit different conformations: chair, half-chair and envelope. In the crystal structure, adjacent eplerenone molecules are linked together via weak intermolecular C—H...O hydrogen bonding, forming a cavity of about 310 Å3, and the dioxane solvent molecules occupy the cavity. The solvent molecule is disordered equally over two positions.